Guo Tianting, Feng Haorong, Xiong Lijiao, Mo Jianwen, Zhang Xiaoan, Xie Junbin, Hu Hongkai
Guangdong Provincial People's Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, Jiangxi, China.
Department of Anesthesiology, South Taihu Hospital Affiliated to Huzhou College (Huzhou South Taihu Hospital), Huzhou, Zhejiang, China.
Front Public Health. 2024 Nov 27;12:1420832. doi: 10.3389/fpubh.2024.1420832. eCollection 2024.
This study investigated the relationship between Geriatric Nutritional Risk Index (GNRI), and all-cause, cardiovascular (CVD) mortality, in individuals with osteopenia and osteoporosis.
Using NHANES data from 2005 to 2019, 6,824 participants diagnosed with osteopenia and osteoporosis were analyzed. Participants were categorized based on GNRI tertiles, and statistical methods like the fitted curves, Kaplan-Meier curves, cox regression, and subgroup analyses were employed.
Lower GNRI tertiles correlated with older age, male gender, and more comorbidities. Mortality rates differed significantly across GNRI tertiles over an average 7.9-year follow-up, with a notable inverse J-shaped association between GNRI and mortality. Adjusted HRs indicated a 1.6-2-fold increase in all-cause mortality for the lowest GNRI tertile, persisting across comprehensive adjustments. CVD mortality followed a similar trend.
This study illuminates a robust correlation between GNRI levels and mortality risks in osteopenia and osteoporosis. Its consistent dose-response relationship across all-cause, and CVD mortality underscores its pivotal role as a prognostic factor.
本研究调查了老年营养风险指数（GNRI）与骨质减少和骨质疏松症患者的全因死亡率、心血管疾病（CVD）死亡率之间的关系。
利用2005年至2019年的美国国家健康与营养检查调查（NHANES）数据，对6824名被诊断为骨质减少和骨质疏松症的参与者进行了分析。参与者根据GNRI三分位数进行分类，并采用了拟合曲线、Kaplan-Meier曲线、Cox回归和亚组分析等统计方法。
较低的GNRI三分位数与年龄较大、男性以及更多的合并症相关。在平均7.9年的随访中，不同GNRI三分位数的死亡率存在显著差异，GNRI与死亡率之间存在明显的倒J形关联。调整后的风险比表明，最低GNRI三分位数的全因死亡率增加了1.6至2倍，在全面调整后仍然存在。CVD死亡率也呈现类似趋势。
本研究揭示了GNRI水平与骨质减少和骨质疏松症患者死亡风险之间的密切关联。其在全因死亡率和CVD死亡率方面一致的剂量反应关系强调了其作为预后因素的关键作用。
