Wang Minggang, Ye Qianling, Mao Dewen, Li Hanmin
Hubei University of Traditional Chinese Medicine, Wuhan, Hubei, China (mainland).
Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China (mainland).
Med Sci Monit. 2020 Mar 7;26:e920310. doi: 10.12659/MSM.920310.
The development, progression, recurrence, and metastasis of hepatocellular carcinoma (HCC) are closely associated with an abnormal liver-regenerating microenvironment (LRM). Therefore, preventing and reversing an abnormal LRM is a potential therapeutic strategy against HCC. Studies are increasingly focusing on the impact of regeneration, fibrosis, angiogenesis, inflammation, immunomodulation, and hepatic stem cells on HCC development and progression. As a key epigenetic mechanism, DNA methylation is extensively involved in regulating physiological and pathological pathways. In this review, we summarize recent findings on the role of DNA methylation in the fibrotic, angiogenic, inflammatory/immune, and stem cell microenvironments of HCC, and discuss new advances in Traditional Chinese Medicine (TCM) on influencing the abnormal LRM, so as to gain new insights into alleviating the abnormal LRM via regulating DNA methylation by TCM.
肝细胞癌（HCC）的发生、发展、复发和转移与异常的肝脏再生微环境（LRM）密切相关。因此，预防和逆转异常的LRM是一种潜在的抗HCC治疗策略。越来越多的研究聚焦于再生、纤维化、血管生成、炎症、免疫调节和肝干细胞对HCC发生发展的影响。作为一种关键的表观遗传机制，DNA甲基化广泛参与调节生理和病理途径。在本综述中，我们总结了DNA甲基化在HCC纤维化、血管生成、炎症/免疫和干细胞微环境中的作用的最新研究结果，并讨论了中医在影响异常LRM方面的新进展，以便通过中医调节DNA甲基化来深入了解缓解异常LRM的新方法。
