Kumar Amarjeet, Kono Hidetoshi
Molecular Modelling and Simulation (MMS) Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum and Radiological Science and Technology (QST), Kizugawa, Kyoto, 619-0215, Japan.
Biophys Rev. 2020 Apr;12(2):387-400. doi: 10.1007/s12551-020-00663-y. Epub 2020 Mar 6.
Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual structural elements of HP1 and thereby different behavior and interaction patterns. Hence, an understanding of various interactions of the structural elements of HP1 will be of utmost importance to better elucidate chromatin dynamics in its presence. In this review, we have gathered available information about interactions of HP1 both within and with itself as well as with chromatin elements. Also, the possible implications of these interactions are discussed.
已知异染色质蛋白1（HP1）的亚型具有多种功能，从基因沉默、基因激活到细胞周期调控和细胞分化。这种功能多样性源于蛋白质序列中编码的差异，这些差异赋予了HP1各个结构元件不同的生物物理和生化特性，从而导致不同的行为和相互作用模式。因此，了解HP1结构元件的各种相互作用对于更好地阐明其存在时的染色质动力学至关重要。在这篇综述中，我们收集了有关HP1内部及其自身之间以及与染色质元件相互作用的现有信息。此外，还讨论了这些相互作用可能产生的影响。
