与2018 - 2019年印度疫情相关的中东谱系牛暂时热病毒（BEFV）的鉴定及系统发育特征分析
Identification and phylogenetic characterization of bovine ephemeral fever virus (BEFV) of Middle Eastern lineage associated with 2018-2019 outbreaks in India.
作者信息
Pyasi Shruti, Sahu Basanta Pravas, Sahoo Priyadarshini, Dubey Pavan Kumar, Sahoo Niranjana, Byrareddy Siddappa N, Nayak Debasis
机构信息
Discipline of Bioscience and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
Swami Vivekananda College of Pharmacy, Indore, India.
出版信息
Transbound Emerg Dis. 2020 Sep;67(5):2226-2232. doi: 10.1111/tbed.13531. Epub 2020 Mar 24.
Bovine ephemeral fever virus (BEFV) is an evolving arbovirus reported across tropical, subtropical and temperate climatic zones globally. This study reveals prominent BEFV outbreaks in India, emerging annually during monsoons in subtropical areas accompanied by a congenial abundance of the vector population. PCR-based detection of viral genomic RNA in the blood samples collected during outbreaks of 2018-2019 for the first time confirmed the presence of BEFV in India. Phylogenetic analysis based on the glycoprotein gene of BEFV showed the current isolates to have high sequence homology with Middle Eastern lineage with nearly 97%, identity to Turkey (BEFV Ad12/TUR) and Israel (Israel 2006) isolates.
牛暂时热病毒（BEFV）是一种不断进化的虫媒病毒，在全球热带、亚热带和温带气候区均有报道。本研究揭示了印度出现的显著BEFV疫情，每年在亚热带地区的季风季节出现，同时伴随着适宜的媒介种群大量繁殖。在2018 - 2019年疫情期间采集的血液样本中，首次通过基于PCR的方法检测病毒基因组RNA，证实了印度存在BEFV。基于BEFV糖蛋白基因的系统发育分析表明，当前分离株与中东谱系具有高度序列同源性，与土耳其（BEFV Ad12/TUR）和以色列（以色列2006）分离株的同一性接近97%。
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