Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St Olav's University Hospital, Trondheim, Norway.
Department of Research, Sunnaas Rehabilitation Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway.
Arch Phys Med Rehabil. 2020 Jun;101(6):939-947. doi: 10.1016/j.apmr.2020.02.006. Epub 2020 Mar 4.
To examine if 8 weeks of high-intensity interval training (HIIT) in addition to standard care would increase and maintain peak oxygen uptake (Vo) more than standard care alone in patients with stroke.
This was a single-blind, multicenter, parallel group, randomized controlled trial.
Specialized rehabilitation units at 3 Norwegian hospitals.
Participants (N=70), 3 months to 5 years after first-ever stroke, were randomly assigned to the intervention group (n=36) or the control group (n=34); 42% were women, mean age was 57.6±9.3 years, mean time post stroke was 26.4±14.5 months.
The intervention was 8 weeks: 3 times a week with HIIT treadmill training with work periods of 4 × 4 minutes at 85%-95% of peak heart rate interspersed with 3 minutes of active recovery at 50%-70% of peak heart rate. The control group received standard care according to national guidelines.
The primary outcome, analyzed by intention-to-treat, was Vo measured as liters per minute 12 months after inclusion. Secondary outcome measures were blood pressure and blood profile.
Mean baseline Vo was 2.63±1.08 L·min vs 2.87±0.71 L·min, while at 12 months Vo was 2.70±1.00 L·min vs 2.67±0.76 L·min (P=.068) in the intervention and control groups, respectively. There was a significant and greater improvement in the intervention group compared with the control group at 12 months in 3 of 6 secondary outcomes from the peak test but no significant differences for blood pressure or blood profile.
The HIIT intervention, which was well-tolerated in this sample of well-functioning survivors of stroke, was not superior to standard care in improving and maintaining Vo at the 12-month follow-up. However, secondary results from the peak test showed a significant improvement from before to immediately after the intervention.
探讨在常规治疗的基础上增加 8 周高强度间歇训练（HIIT）是否比单纯常规治疗更能增加和维持脑卒中后患者的峰值摄氧量（Vo）。
这是一项单盲、多中心、平行组、随机对照试验。
挪威 3 家医院的专门康复单位。
70 名参与者，在首次中风后 3 个月至 5 年内，随机分为干预组（n=36）或对照组（n=34）；42%为女性，平均年龄 57.6±9.3 岁，中风后平均时间为 26.4±14.5 个月。
干预措施为 8 周：每周 3 次，使用 HIIT 跑步机训练，工作期为 4×4 分钟，心率达到峰值的 85%-95%，间歇期为 3 分钟，心率达到峰值的 50%-70%。对照组根据国家指南接受常规治疗。
主要结局指标（按意向治疗分析）为纳入后 12 个月 Vo 测量值（以升/分钟计）。次要结局指标为血压和血液状况。
平均基线 Vo 为 2.63±1.08 L·min，而干预组和对照组在 12 个月时分别为 2.70±1.00 L·min 和 2.67±0.76 L·min（P=.068）。在干预组与对照组相比，在 12 个月时，在 6 项次要结局中有 3 项在峰值测试中显示出显著和更大的改善，但血压或血液状况无显著差异。
在本研究中，该 HIIT 干预方案在功能良好的脑卒中幸存者中耐受良好，但在改善和维持 12 个月时的 Vo 方面并不优于常规治疗。然而，峰值测试的次要结果显示，干预后即刻与干预前相比有显著改善。
