School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Fitoterapia. 2020 Apr;142:104536. doi: 10.1016/j.fitote.2020.104536. Epub 2020 Mar 5.
Commiphoins A-C (1-3), three new cadinane-type sesquiterpenes, together with two known cadinane-type sesquiterpenes (4 and 5) were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were established on the basis of comprehensive spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses. Compounds 1 and 3-5 were screened for anti-Alzheimer's disease (AD) activities using the AD pathological model in Caenorhabditis elegans. The results showed that they all had significant anti-AD activities.
_commiphoins A-C (1-3)，三种新的卡丹烷型倍半萜，以及两种已知的卡丹烷型倍半萜 (4 和 5)，从 Commiphora myrrha 的树脂分泌物中分离得到。它们的结构和相对构型是基于综合光谱方法确定的，包括 HRESIMS、1D 和 2D NMR 分析。化合物 1 和 3-5 采用秀丽隐杆线虫 AD 病理模型筛选抗 AD 活性。结果表明，它们均具有显著的抗 AD 活性。
