陷窝：形成、动态和功能。

Caveolae: Formation, dynamics, and function.

机构信息

The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia; The University of Queensland, Centre for Microscopy and Microanalysis, Brisbane, Queensland, 4072, Australia.

The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia.

出版信息

Curr Opin Cell Biol. 2020 Aug;65:8-16. doi: 10.1016/j.ceb.2020.02.001. Epub 2020 Mar 6.

DOI:10.1016/j.ceb.2020.02.001

PMID:32146331

Abstract

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane lipids. This membranous assembly can bud off into the cell or can be disassembled releasing the cavin proteins into the cytosol. Disassembly can be triggered by increased membrane tension, or by stress stimuli, such as UV. Here, we discuss recent mechanistic studies showing how caveolae are formed and how their unique properties allow them to function as multifunctional protective and signaling structures.

摘要

小窝是由细胞质蛋白在由窖蛋白整合膜蛋白和膜脂生成的平台上组装形成的丰富的表面凹陷。这种膜性组装可以出芽进入细胞，也可以通过解体将窖蛋白释放到细胞质溶胶中。解体可以由膜张力增加触发，也可以由应激刺激触发，如紫外线。在这里，我们讨论了最近的机制研究，这些研究表明了小窝是如何形成的，以及它们独特的特性如何使它们能够作为多功能的保护和信号结构发挥作用。