School of Psychology and Key Laboratory of Cognition and Personality (Ministry of Education); National Demonstration Center for Experimental Psychology Education, Southwest University, Chongqing 400715, China.
Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, ON, Canada.
J Trace Elem Med Biol. 2020 Jul;60:126478. doi: 10.1016/j.jtemb.2020.126478. Epub 2020 Feb 27.
Alkali metals (AMs) and alkali earth metals (AEMs) affect levels and signaling of neurotransmitters, which potentially play a role in the etiology of schizophrenia (SCZ). The current case-control study aims to explore how AMs [i.e. Potassium (K), sodium (Na), rubidium (Rb), cesium (Cs)] and AEMs [i.e. magnesium (Mg), calcium (Ca), strontium (Sr), barium (Ba)] in serum could associate with SCZ. One hundred and five inpatients with SCZ and 106 age- and sex-matched healthy controls (HCs) were recruited from Weifang, China. Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) was used to evaluate serum concentrations of Na, K, Ca, Mg and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was for Rb, Cs, Sr, Ba. Subjects with SCZ had significantly higher Mg and Sr serum concentrations than HCs (20.86 vs. 19.73 μg/mL of Mg, p < 0.001; 53.14 vs. 42.26 ng/mL of Sr, p < 0.001). After adjusting for confounders, the odds ratio of Mg and Sr remain significantly higher in the SCZ group (Mg: OR = 2.538, 95 % CI: 1.254-5.136, p=0.010; Sr: OR = 3.798, 95 % CI: 1.769-8.153, p = 0.001). No significant differences between SCZ subjects and HCs were observed for other AMs and AEMs. Higher serum concentrations of Mg and Sr were associated with SCZ. Studies are suggested to find the related mechanisms and provide clues for pathogenesis of SCZ, which would impact prevention and treatments of SCZ.
碱金属（AMs）和碱土金属（AEMs）会影响神经递质的水平和信号转导，这可能在精神分裂症（SCZ）的发病机制中发挥作用。本病例对照研究旨在探讨血清中的 AMs[即钾（K）、钠（Na）、铷（Rb）、铯（Cs）]和 AEMs[即镁（Mg）、钙（Ca）、锶（Sr）、钡（Ba）]如何与 SCZ 相关。我们从中国潍坊招募了 105 名精神分裂症住院患者和 106 名年龄和性别匹配的健康对照者（HCs）。采用电感耦合等离子体原子发射光谱法（ICP-AES）评估血清中 Na、K、Ca、Mg 的浓度，采用电感耦合等离子体质谱法（ICP-MS）评估 Rb、Cs、Sr、Ba 的浓度。与 HCs 相比，精神分裂症患者的血清 Mg 和 Sr 浓度明显更高（Mg：20.86 对 19.73μg/mL，p<0.001；Sr：53.14 对 42.26ng/mL，p<0.001）。在校正混杂因素后，精神分裂症组的 Mg 和 Sr 的比值仍明显更高（Mg：OR=2.538，95%CI：1.254-5.136，p=0.010；Sr：OR=3.798，95%CI：1.769-8.153，p=0.001）。精神分裂症患者和 HCs 之间的其他 AMs 和 AEMs 无显著差异。更高的血清 Mg 和 Sr 浓度与 SCZ 相关。建议进行研究以寻找相关机制，并为 SCZ 的发病机制提供线索，这将影响 SCZ 的预防和治疗。
