Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Department of Biochemistry and Molecular Biology, Research Center of Laboratory Medicine, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China.
Drug Resist Updat. 2020 May;50:100683. doi: 10.1016/j.drup.2020.100683. Epub 2020 Feb 25.
Chemoresistance including intrinsic and acquired anticancer drug resistance continues to be a primary hindrance towards curative cancer treatment. Therefore, deciphering the underlying molecular mechanisms is of paramount importance required towards the overcoming of chemoresistance. Cumulative evidence revealed that long non-coding RNAs (lncRNAs) play a pivotal role in conferring anticancer drug resistance upon a broad spectrum of cancers. Hence, numerous lncRNAs are recognized as novel biomarkers and therapeutic targets in the diagnosis and treatment of malignancies, which urges us to comprehensively delineate the critical functions of lncRNAs in chemoresistance. In this respect, we herein succinctly elucidate the molecular mechanisms by which lncRNAs modulate their downstream targets to mediate cancer chemoresistance. Therefore, the current review may provide a significant basis for the future conquering of chemoresistance via targeting lncRNAs in cancer therapeutics.
化疗耐药性包括内在和获得性抗癌药物耐药性，仍然是治愈癌症治疗的主要障碍。因此，解析潜在的分子机制对于克服化疗耐药性至关重要。累积的证据表明，长链非编码 RNA（lncRNA）在广泛的癌症中赋予抗癌药物耐药性方面发挥着关键作用。因此，许多 lncRNA 被认为是恶性肿瘤诊断和治疗中的新型生物标志物和治疗靶点，这促使我们全面描绘 lncRNA 在化疗耐药性中的关键功能。在这方面，我们简要阐明了 lncRNA 通过调节其下游靶标来介导癌症化疗耐药性的分子机制。因此，本综述可能为通过在癌症治疗中靶向 lncRNA 来克服化疗耐药性提供重要依据。
