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Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses.

作者信息

Inczefi O, Bacquié V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamène H, Bétoulières C, Thomas J, Lainé J, Gros L, Lévêque M, Leonard R, Harkat C, Robbe-Masselot C, Róka R, Mercier-Bonin M, Theodorou V, Darnaudéry M, Turner J R, Ferrier L

机构信息

UMR 1331 ToxAlim, French National Institute for Agriculture, Food, and Environment, Toulouse, France; First Department of Medicine, University of Szeged, Szeged, Hungary.

UMR 1331 ToxAlim, French National Institute for Agriculture, Food, and Environment, Toulouse, France.

出版信息

Cell Mol Gastroenterol Hepatol. 2020;10(1):206-208.e3. doi: 10.1016/j.jcmgh.2020.02.008. Epub 2020 Mar 6.

DOI:10.1016/j.jcmgh.2020.02.008
PMID:32147490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7296230/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/53387ce65a06/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/8b7e788178e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/b0bf94a492ea/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/591fe3613554/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/53387ce65a06/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/8b7e788178e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/b0bf94a492ea/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/591fe3613554/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf7/7296230/53387ce65a06/fx2.jpg

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Psychopharmacology (Berl). 2019 May;236(5):1583-1596. doi: 10.1007/s00213-019-05252-w. Epub 2019 May 23.
2
Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome.肠通透性与脑结构和功能在健康和肠易激综合征中的相互作用。
Neuroimage Clin. 2019;21:101602. doi: 10.1016/j.nicl.2018.11.012. Epub 2018 Nov 17.
3
Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats.
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Front Immunol. 2024 Sep 5;15:1434804. doi: 10.3389/fimmu.2024.1434804. eCollection 2024.
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The gut microbiota in thrombosis.血栓形成中的肠道微生物群
Nat Rev Cardiol. 2025 Feb;22(2):121-137. doi: 10.1038/s41569-024-01070-6. Epub 2024 Sep 17.
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Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice.造血细胞中前啡肽原的缺失会导致肠道屏障功能衰竭，从而使小鼠出现类似于肠易激综合征的临床特征。
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