Social, Economic and Administrative Pharmacy (SEAP) Graduate Program, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Expert Rev Gastroenterol Hepatol. 2020 Apr;14(4):291-300. doi: 10.1080/17474124.2020.1740087. Epub 2020 Mar 16.
: The study aimed to assess the overall and stage-specific colorectal cancer (CRC) survival and to identify the prognostic factors for survival among Thai patients.: The retrospective data of CRC patients from a university hospital-based cancer registry from 2001 to 2014 were used to estimate five-year overall survival (OS). Kaplan-Meier method and log-rank tests were used to assess the differences in five-year OS by age at diagnosis, diagnostic period, tumor site, stage at diagnosis and treatment modalities. A multivariate Cox's proportional hazard model was used to identify independent prognostic factors for the OS.: A total of 1,507 (48%) colon and 1,648 (52%) rectal cancer patients were included. Five-year OS for CRC patients was 44%. It differed significantly by stage, age group, and treatment received. Stage at diagnosis, age group, diagnostic period, receiving surgical and chemotherapy treatments were prognostic factors for OS.: An increasing trend in the number of CRC patients mostly at stage III and IV was found. Our results emphasized that an improvement in CRC survival could be achieved through the adoption of advanced cancer therapies, as well as improved access to quality diagnosis and timely treatment.
: 本研究旨在评估泰国患者的总体和特定阶段结直肠癌(CRC)生存情况,并确定生存的预后因素。: 本研究使用了 2001 年至 2014 年一家大学医院癌症登记处的 CRC 患者回顾性数据来估计五年总体生存率(OS)。Kaplan-Meier 方法和对数秩检验用于评估诊断时年龄、诊断期、肿瘤部位、诊断时分期和治疗方式对五年 OS 的差异。多变量 Cox 比例风险模型用于确定 OS 的独立预后因素。: 共纳入 1507 例(48%)结肠癌和 1648 例(52%)直肠癌患者。CRC 患者的五年 OS 为 44%。它在分期、年龄组和所接受的治疗方面有显著差异。诊断时的分期、年龄组、诊断期、接受手术和化疗治疗是 OS 的预后因素。: 发现 CRC 患者的数量呈上升趋势,主要集中在 III 期和 IV 期。我们的结果强调,通过采用先进的癌症治疗方法,以及改善获得高质量诊断和及时治疗的机会,CRC 的生存状况可以得到改善。