Li Xiao-Ran, Liu Chen-Jian, Tang Xiao-Dan, Zhang He-Ming, Luo Yi-Yong, Zhang Le, Yang En
Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong, Kunming 650500, Yunnan, China.
Department of Gastroenterology, First People Hospital of Yunnan Province, Kunming 650032, Yunnan, China.
Can J Infect Dis Med Microbiol. 2020 Feb 18;2020:4583973. doi: 10.1155/2020/4583973. eCollection 2020.
The objective of this study was to evaluate the effects of a three-strain yogurt formulation in slow-transit constipation (STC) patients. Each individual in both treatment groups consumed 250 mL of the formulated yogurt daily for a week (7 days), and fecal samples were collected for gut microbiota and short-chain fatty acid (SCFA) analyses. A significant increase in the defection frequency ( < 0.001) and bacterial diversity (=0.027) at the 100% sequence homology level and a decrease in the concentrations of acetic acid (=0.014), propionic acid (=0.019), and butanoic acid (=0.005) were observed after the STC patients consumed three-strain yogurt formulation. In addition, the consumption of the three-strain yogurt formulation significantly altered the composition of the intestinal bacteria in the STC patients. The relative abundances of 23 genera in the top dominating genera were altered significantly after the STC patients consumed the yogurt. In summary, the consumption of 250 mL day the three-strain yogurt formulation described in this study can play a role in improving the symptoms of STC.
本研究的目的是评估一种三菌株酸奶配方对慢传输型便秘（STC）患者的影响。两个治疗组中的每位受试者每天食用250毫升配方酸奶，持续一周（7天），并收集粪便样本进行肠道微生物群和短链脂肪酸（SCFA）分析。STC患者食用三菌株酸奶配方后，在100%序列同源性水平下，排便频率显著增加（<0.001），细菌多样性增加（=0.027），同时乙酸（=0.014）、丙酸（=0.019）和丁酸（=0.005）浓度降低。此外，食用三菌株酸奶配方显著改变了STC患者肠道细菌的组成。STC患者食用酸奶后，23个优势属中的相对丰度发生了显著变化。总之，本研究中描述的每天食用250毫升三菌株酸奶配方可在改善STC症状方面发挥作用。
