Lopez Kelsey M, Ravula Sudhir, Pérez Rocío L, Ayala Caitlan E, Losso Jack N, Janes Marlene E, Warner Isiah M
Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Science Center, New Orleans, Louisiana 70119, United States.
ACS Omega. 2020 Feb 21;5(8):4125-4132. doi: 10.1021/acsomega.9b03852. eCollection 2020 Mar 3.
A facile method was used to synthesize biocomposites containing differing ratios of hyaluronic acid (HA) and cellulose (CEL). Based on the properties of the individual polymers, the resultant composite materials may have potentially great wound care properties. In the method outlined here, 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]), a simple ionic liquid, was used as the sole solvent without chemical modifiers to dissolve the biopolymers at ratios of 1:1 and 2:1 HA to CEL. This method was completely recyclable since the ionic liquid, [Bmim][Cl], can be recovered. Results from spectroscopic measurements [Fourier transform infrared (FT-IR) and X-ray diffraction (XRD)] confirm the interaction between HA and CEL. Scanning electron microscopy (SEM) images reflect differing biopolymer ratios and the resulting impact on the texture and porosity of these composite materials. The composites exhibited high swelling capacity in various media. These composites were also drug-loaded to examine drug release properties for greater potential in combating infections.
采用一种简便方法合成了含有不同比例透明质酸（HA）和纤维素（CEL）的生物复合材料。基于各聚合物的特性，所得复合材料可能具有潜在的优异伤口护理性能。在此所述方法中，一种简单的离子液体1-丁基-3-甲基咪唑氯盐（[Bmim][Cl]）被用作唯一溶剂，无需化学改性剂，以1:1和2:1的HA与CEL比例溶解生物聚合物。该方法完全可回收利用，因为离子液体[Bmim][Cl]可以回收。光谱测量结果[傅里叶变换红外光谱（FT-IR）和X射线衍射（XRD）]证实了HA与CEL之间的相互作用。扫描电子显微镜（SEM）图像反映了不同的生物聚合物比例以及对这些复合材料质地和孔隙率的影响。这些复合材料在各种介质中表现出高溶胀能力。这些复合材料还进行了载药处理，以研究药物释放特性，在对抗感染方面具有更大潜力。
