From the Department of General Medicine, Royal Children's Hospital, Melbourne, Australia.
SAEFVIC, Murdoch Children's Research Institute.
Pediatr Infect Dis J. 2020 Jun;39(6):e66-e68. doi: 10.1097/INF.0000000000002630.
Bacille Calmete-Guerin vaccine is widely administered to reduce the risk of severe tuberculosis disease in children. Recent global vaccine supply issues have led to the use of alternative products, which may vary in side effect profile. We report on the safety of the Polish (Moreau strain) "Bacille Calmete-Guerin-10" vaccine in an Australian cohort. Using active surveillance, we identified an adverse event rate of 54.6 per 10,000 doses (95% confidence interval: 38.5-75.2), which was comparable to that reported with the Danish Sanofi-Pasteur and Connaught strains.
卡介苗疫苗被广泛应用于降低儿童罹患严重结核病的风险。近期全球疫苗供应问题导致替代产品的使用，而这些替代产品的副作用谱可能有所不同。我们报告了在澳大利亚队列中使用波兰（莫罗株）“卡介苗-10”疫苗的安全性。通过主动监测，我们发现每 10000 剂疫苗的不良事件发生率为 54.6 例（95%置信区间：38.5-75.2），与丹麦赛诺菲巴斯德和康诺特株报告的结果相当。
