Andrade de Souza Ramon, Rodrigues Barreto Florisneide, Antônio de Souza Teles Santos Carlos, Silva Nery Joilda, Cristina Oliveira de Jesus Lima Carla, Soares Castelo Isabella, Natividade Marcio, Amaral Freire de Andrade Jacy, Lima Barreto Maurício, Martins Pereira Susan
Institute of Collective Health, Federal University of Bahia, Bahia, Brazil.
Centre for Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Bahia, Brazil.
Vaccine X. 2023 Jun 7;14:100323. doi: 10.1016/j.jvacx.2023.100323. eCollection 2023 Aug.
In Brazil, in 1925, the strain was introduced, and since its implementation, it has been the routine vaccine for health services. Since 2013, many countries, including Brazil, have been experiencing problems with the production of vaccines. As of January 2018, the country started to use the BCG vaccine with strain, developed by the Serum Institute India.
To describe the evolution of the vaccine scar in neonates vaccinated by BCG- compared to BCG-.
This was a cohort study was conducted in Salvador city, northeast Brazil. The study population consisted of newborns from the reference maternity hospital, who were vaccinated with BCG-ID strains or , followed up to assess vaccine lesion evolution.
It was observed that regardless of the vaccine strains, the evolution of the lesion was the same: wheal, reddish macula, induration, pustule, ulcer, and scar. The proportion of vaccine scar in the group vaccinated with BCG was lower than that of BCG , 62.5 % and 90.9 %, respectively, with a statistically significant difference.
The evolution of the scar by BCG- was similar to the Moreau scar, however different proportions were observed in different stages of lesion between the groups.
1925年，该菌株在巴西被引入，自实施以来，它一直是卫生服务的常规疫苗。自2013年以来，包括巴西在内的许多国家在疫苗生产方面一直面临问题。截至2018年1月，该国开始使用由印度血清研究所研发的卡介苗菌株。
描述与卡介苗-相比，接种卡介苗-的新生儿疫苗疤痕的演变情况。
这是一项在巴西东北部萨尔瓦多市进行的队列研究。研究人群包括来自参考妇产医院的新生儿，他们接种了卡介苗-ID菌株或，随访以评估疫苗损伤的演变。
观察到无论疫苗菌株如何，损伤的演变都是相同的：风团、微红斑、硬结、脓疱、溃疡和疤痕。接种卡介苗组的疫苗疤痕比例低于卡介苗组，分别为62.5%和90.9%，差异有统计学意义。
卡介苗-的疤痕演变与莫罗疤痕相似，但两组在损伤的不同阶段观察到不同比例。
