Evolution of the scar and strains in newborns: A brazilian cohort.

BACKGROUND

In Brazil, in 1925, the strain was introduced, and since its implementation, it has been the routine vaccine for health services. Since 2013, many countries, including Brazil, have been experiencing problems with the production of vaccines. As of January 2018, the country started to use the BCG vaccine with strain, developed by the Serum Institute India.

OBJECTIVE

To describe the evolution of the vaccine scar in neonates vaccinated by BCG- compared to BCG-.

METHODS

This was a cohort study was conducted in Salvador city, northeast Brazil. The study population consisted of newborns from the reference maternity hospital, who were vaccinated with BCG-ID strains or , followed up to assess vaccine lesion evolution.

RESULTS

It was observed that regardless of the vaccine strains, the evolution of the lesion was the same: wheal, reddish macula, induration, pustule, ulcer, and scar. The proportion of vaccine scar in the group vaccinated with BCG was lower than that of BCG , 62.5 % and 90.9 %, respectively, with a statistically significant difference.

CONCLUSION

The evolution of the scar by BCG- was similar to the Moreau scar, however different proportions were observed in different stages of lesion between the groups.