Baek Hey-Sung, Jeong Jae-Won, Lee Ha-Baik, Kwon Jae-Woo
Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul.
Inje University Ilsan Paik Hospital, Goyang.
Medicine (Baltimore). 2020 Mar;99(10):e19469. doi: 10.1097/MD.0000000000019469.
The profiles of sensitization based on component-resolved diagnosis (CRD) differ from region to region in populations sensitized to birch pollen. We investigated the endotypes of birch pollen-sensitized Korean children with allergic diseases using CRD and distinguished the endotypes of oral allergy syndrome (OAS) among them.Thirty-one birch pollen-sensitized children with allergic diseases were enrolled. Specific immunoglobulin E (IgE) to birch pollen and fruit including apple, peach, and kiwi were evaluated via skin prick tests and ImmunoCAP in all subjects. Sensitization profiles based on CRD were evaluated with the Immuno-solid-phase Allergen Chip for birch pollen-sensitization using birch pollen components (Bet v 1, Bet v 2, and Bet v 4), and for OAS using the allergen families pathogenesis-related class 10 proteins (PR-10), lipid transfer proteins, and profilin.All patients (n = 13) with OAS were sensitive to Bet v 1. However, 61% (11/18) of patients without OAS were sensitized to Bet v 1. The level of specific IgE to Bet v 1 was higher in patients with OAS than in those without OAS. All birch pollen-sensitized Korean children with OAS were sensitized to PR-10, and 69% (9/13) of them were mono-sensitized to PR-10. Among patients without OAS, 33% (6/18) were not sensitized to any of the allergen families.Birch pollen-sensitized Korean children with allergic diseases showed unique patterns of sensitization to Bet v 1, Bet v 2, and Bet v 4, and the sensitization profiles based on CRD were totally different according to the presence of OAS.
在对桦树花粉过敏的人群中，基于组分解析诊断（CRD）的致敏谱因地区而异。我们使用CRD研究了患有过敏性疾病的桦树花粉致敏韩国儿童的内型，并区分了其中口腔过敏综合征（OAS）的内型。招募了31名患有过敏性疾病的桦树花粉致敏儿童。通过皮肤点刺试验和免疫化学发光法（ImmunoCAP）评估了所有受试者对桦树花粉以及苹果、桃子和猕猴桃等水果的特异性免疫球蛋白E（IgE）。使用免疫固相过敏原芯片，基于桦树花粉组分（Bet v 1、Bet v 2和Bet v 4）评估CRD的桦树花粉致敏谱，基于病程相关类10蛋白（PR-10）、脂质转移蛋白和肌动蛋白结合蛋白评估OAS的致敏谱。所有OAS患者（n = 13）均对Bet v 1敏感。然而，61%（11/18）无OAS的患者对Bet v 1致敏。OAS患者中Bet v 1的特异性IgE水平高于无OAS的患者。所有患有OAS的桦树花粉致敏韩国儿童均对PR-10致敏，其中69%（9/13）为单一致敏于PR-10。在无OAS的患者中，33%（6/18）对任何过敏原家族均未致敏。患有过敏性疾病的桦树花粉致敏韩国儿童对Bet v 1、Bet v 2和Bet v 4表现出独特的致敏模式，基于CRD的致敏谱根据是否存在OAS而完全不同。
