Kim Mi Ae, Kim Dong Kyu, Yang Hyeon Jong, Yoo Young, Ahn Youngmin, Park Hae Sim, Lee Hyun Jong, Jeong Yi Yeong, Kim Bong Seong, Bae Woo Yong, Jang An Soo, Park Yang, Koh Young Il, Lee Jaechun, Lim Dae Hyun, Kim Jeong Hee, Lee Sang Min, Kim Yong Min, Jun Young Joon, Kim Hyo Yeol, Kim Yunsun, Choi Jeong Hee
Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Chuncheon Sacred Heart Hospital and Nano-Bio Regenerative Medical Institute, Hallym University College of Medicine, Chuncheon, Korea.
Allergy Asthma Immunol Res. 2018 Nov;10(6):648-661. doi: 10.4168/aair.2018.10.6.648.
Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea.
Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled. The questionnaires included demographic characteristics, a list of fruits and vegetables, and clinical manifestations of food allergy. Pollen allergy was diagnosed by skin prick test and/or measurement of the serum level of specific IgE.
A total of 648 pollinosis patients were enrolled. The prevalence of PFAS was 41.7% (n = 270). PFAS patients exhibited cutaneous (43.0%), respiratory (20.0%), cardiovascular (3.7%) or neurologic symptoms (4.8%) in addition to oropharyngeal symptoms. Anaphylaxis was noted in 8.9% of the PFAS patients. Seventy types of foods were linked to PFAS; e.g., peach (48.5%), apple (46.7%), kiwi (30.4%), peanut (17.4%), plum (16.3%), chestnut (14.8%), pineapple (13.7%), walnut (14.1%), Korean melon (12.6%), tomato (11.9%), melon (11.5%) and apricot (10.7%). Korean foods such as taro/taro stem (8.9%), ginseong (8.2%), perilla leaf (4.4%), bellflower root (4.4%), crown daisy (3.0%), deodeok (3.3%), kudzu root (3.0%) and lotus root (2.6%) were also linked to PFAS.
This was the first nationwide study of PFAS in Korea. The prevalence of PFAS was 41.7%, and 8.9% of the PFAS patients had anaphylaxis. These results will provide clinically useful information to physicians.
花粉 - 食物过敏综合征（PFAS）是花粉症患者中由生水果和蔬菜引起的免疫球蛋白E（IgE）介导的过敏反应，是成人中最常见的食物过敏。然而，韩国尚未有关于PFAS的全国性研究。在本研究中，我们调查了韩国PFAS的患病率和临床特征。
22名研究人员参与了本研究，纳入了患有过敏性鼻结膜炎和/或支气管哮喘且对花粉过敏的患者。问卷包括人口统计学特征、水果和蔬菜清单以及食物过敏的临床表现。通过皮肤点刺试验和/或测量特异性IgE血清水平诊断花粉过敏。
共纳入648例花粉症患者。PFAS的患病率为41.7%（n = 270）。PFAS患者除口咽症状外，还表现出皮肤症状（43.0%）、呼吸道症状（20.0%）、心血管症状（3.7%）或神经症状（4.8%）。8.9%的PFAS患者发生过敏反应。70种食物与PFAS有关；例如，桃子（48.5%）、苹果（46.7%）、猕猴桃（30.4%）、花生（17.4%）、李子（16.3%）、栗子（14.8%）、菠萝（13.7%）、核桃（14.1%）、韩国甜瓜（12.6%）、番茄（11.9%）、甜瓜（11.5%）和杏子（10.7%）。韩国食物如芋头/芋梗（8.9%）、锦橙（8.2%）、紫苏叶（4.4%）、桔梗根（4.4%）、茼蒿（3.0%）、沙参（3.3%）、葛根（3.0%）和莲藕（2.6%）也与PFAS有关。
这是韩国首次关于PFAS的全国性研究。PFAS的患病率为41.7%，8.9%的PFAS患者发生过敏反应。这些结果将为医生提供临床有用信息。
