Cheng Yaya, Jiao Xiangyu, Fan Wenpei, Yang Zhen, Wen Yongqiang, Chen Xiaoyuan
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing, 100083, PR China; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing, 100083, PR China.
Biomaterials. 2020 Oct;256:120191. doi: 10.1016/j.biomaterials.2020.120191. Epub 2020 Jun 20.
Despite the advantages of mesoporous silica nanoparticles (MSNs) in drug delivery, the inherent non-biodegradability seriously impedes the clinical translation of inorganic MSNs, so the current research focus has been turned to mesoporous organosilica nanoparticles (MONs) with higher biocompatibility and easier biodegradability. Recent remarkable advances in silica fabrication chemistry have catalyzed the emergence of a library of MONs with various structures and functions. This review will summarize the latest state-of-the-art studies on the precise control of morphology, structure, framework, particle size and pore size of MONs, which enables the precise synthesis of MONs with suitable engineering for precision stimuli-responsive drug delivery/release, bioimaging and synergistic therapy. Besides, the potential challenges about the future development of MONs are also outlooked with the intention of attracting more researchers to promote the clinical translation of MONs.
尽管介孔二氧化硅纳米颗粒（MSNs）在药物递送方面具有优势，但其固有的不可生物降解性严重阻碍了无机MSNs的临床转化，因此目前的研究重点已转向具有更高生物相容性和更易生物降解性的介孔有机硅纳米颗粒（MONs）。二氧化硅制备化学领域最近的显著进展催生了一系列具有各种结构和功能的MONs。本综述将总结关于MONs形态、结构、骨架、粒径和孔径精确控制的最新前沿研究，这些研究能够精确合成具有合适工程设计的MONs，用于精确的刺激响应性药物递送/释放、生物成像和协同治疗。此外，还展望了MONs未来发展面临的潜在挑战，旨在吸引更多研究人员推动MONs的临床转化。
