Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
BMJ Open. 2020 Mar 8;10(3):e033741. doi: 10.1136/bmjopen-2019-033741.
To develop a tool to inform individuals and general practitioners about benefits of lifestyle changes by providing estimates of the expected age of death (EAD) for different risk factor values, and for those who plan and decide on preventive activities and health services at population level, to calculate potential need for these.
Prospective cohort study to estimate EAD using a model with 27 established risk factors, categorised into four groups: (1) sociodemographic background and medical history, (2) lifestyles, (3) life satisfaction, and (4) biological risk factors. We apply a Poisson regression model on the survival data split into 1-year intervals.
Total of 38 549 participants aged 25-74 years at baseline of the National FINRISK Study between 1987 and 2007.
Register-based comprehensive mortality data from 1987 to 2014 with an average follow-up time of 16 years and 4310 deaths.
Almost all risk factors included in the model were statistically significantly associated with death. The largest influence on the EAD appeared to be a current heavy smoker versus a never smoker as the EAD for a 30-year-old man decreased from 86.8 years, which corresponds to the reference values of the risk factors, to 80.2 years. Diabetes decreased EAD by >6.6 years. Whole or full milk consumers had 3.4 years lower EAD compared with those consuming skimmed milk. Physically inactive men had 2.4 years lower EAD than those with high activity. Men who found their life almost unbearable due to stress had 2.8 years lower EAD.
The biological risk factors and lifestyles, and the factors connected with life satisfaction were clearly associated with EAD. Our model for estimating a person's EAD can be used to motivate lifestyle changes.
通过提供不同风险因素值的预期死亡年龄(EAD)估计值,以及为那些在人群层面上计划和决定预防活动和卫生服务的个人和全科医生提供相关信息,开发一种工具,使他们了解生活方式改变的益处。
前瞻性队列研究,使用包含 27 个已确立风险因素的模型来估计 EAD,这些风险因素分为四组:(1)社会人口统计学背景和病史,(2)生活方式,(3)生活满意度,和(4)生物风险因素。我们在生存数据上应用泊松回归模型,将其分为 1 年间隔。
1987 年至 2007 年期间参加国家 FINRISK 研究的总计 38549 名年龄在 25-74 岁的基线参与者。
1987 年至 2014 年的基于登记的综合死亡率数据,平均随访时间为 16 年,有 4310 人死亡。
模型中包含的几乎所有风险因素与死亡均具有统计学显著相关性。对 EAD 影响最大的似乎是当前重度吸烟者与从不吸烟者相比,一名 30 岁男性的 EAD 从 86.8 岁(对应于风险因素的参考值)降至 80.2 岁。糖尿病使 EAD 降低了>6.6 年。与食用脱脂牛奶的人相比,全脂或全脂牛奶消费者的 EAD 低 3.4 年。与高活动量的男性相比,不活跃的男性的 EAD 低 2.4 年。由于压力而感到生活几乎无法忍受的男性的 EAD 低 2.8 年。
生物风险因素和生活方式以及与生活满意度相关的因素与 EAD 明显相关。我们用于估计个人 EAD 的模型可用于激励生活方式的改变。