Akorn Pharmaceuticals, Vernon Hills, IL, USA.
School of Basic Pharmaceutical & Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
Arch Pharm Res. 2020 Apr;43(4):371-384. doi: 10.1007/s12272-020-01225-2. Epub 2020 Mar 10.
Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against multiple cancer types including pancreatic, prostate, breast, lung, cervical, and colorectal cancers. Sulforaphane exerts its therapeutics action by a variety of mechanisms, such as by detoxifying carcinogens and oxidants through blockage of phase I metabolic enzymes, and by arresting cell cycle in the G2/M and G1 phase to inhibit cell proliferation. The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel, docetaxel, and gemcitabine through additive and synergistic effects. Although a good number of reviews have reported on the mechanisms by which sulforaphane exerts its anticancer activity, a comprehensive review on the synergistic effect of sulforaphane and its delivery strategies is lacking. Therefore, the aim of the current review was to provide a summary of the studies that have been reported on the activity enhancement effect of sulforaphane in combination with other anticancer therapies. Also provided is a summary of the strategies that have been developed for the delivery of sulforaphane.
萝卜硫素是一种异硫氰酸酯化合物，已从十字花科蔬菜中提取出来。大量研究表明，它对多种癌症类型具有活性，包括胰腺癌、前列腺癌、乳腺癌、肺癌、宫颈癌和结直肠癌。萝卜硫素通过多种机制发挥其治疗作用，例如通过阻断 I 相代谢酶来解毒致癌物质和氧化剂，以及通过将细胞周期阻滞在 G2/M 和 G1 期来抑制细胞增殖。最引人注目的观察结果是萝卜硫素能够通过加性和协同作用增强包括紫杉醇、多西他赛和吉西他滨在内的几类抗癌药物的活性。尽管有许多评论报告了萝卜硫素发挥抗癌活性的机制，但缺乏关于萝卜硫素协同作用及其传递策略的综合综述。因此，本综述的目的是总结已报道的萝卜硫素与其他抗癌疗法联合使用的增强活性的研究。还总结了萝卜硫素传递策略的发展。
