Yuan Taoyang, Zuo Zhentao, Ying Jianyou, Jin Lu, Kang Jie, Gui Songbai, Wang Rui, Li Chuzhong
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Front Neurosci. 2020 Feb 20;14:10. doi: 10.3389/fnins.2020.00010. eCollection 2020.
The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal lobe (MTL) in patients with unilateral MTL glioma.
Sixty-eight patients with unilateral MTL glioma (left MTL glioma, = 33; right MTL glioma, = 35) and 40 healthy controls were recruited and scanned with 3D T1 MRI and rest-fMRI. We explored the structure of the contralesional MTL using voxel-based morphometry (VBM) and assessed the memory networks of the contralesional hemisphere using resting-state functional connectivity (rs-FC). The association between FC and cognitive function was assessed with partial correlation analysis.
Compared with healthy controls, both patient groups exhibited (1) a large cluster of voxels with gray matter (GM) volume decrease in the contralesional MTL using region of interest (ROI)-based VBM analysis (cluster level < 0.05, FDR corrected); and (2) decreased intrahemispheric FC between the posterior hippocampus (pHPC) and posterior cingulate cortex (PCC) ( < 0.01, Bonferroni corrected). Intrahemispheric FC between the pHPC and PCC was positively correlated with cognitive function in both patient groups.
Using multi-modality brain imaging tools, we found structural and functional changes in the contralesional MTL in patients with unilateral MTL glioma. These findings suggest that the contralesional cortex may have decompensation of structure and function in patients with unilateral glioma, except for compensatory structural and functional adaptations. Our study provides additional insight into the neuroanatomical and functional network changes in the contralesional cortex in patients with glioma.
人类大脑具有非凡的能力，能够根据疾病在功能上改变或重组其结构。本研究旨在评估单侧内侧颞叶（MTL）胶质瘤患者对侧MTL的结构和功能可塑性。
招募了68名单侧MTL胶质瘤患者（左侧MTL胶质瘤，n = 33；右侧MTL胶质瘤，n = 35）和40名健康对照者，并使用3D T1 MRI和静息态功能磁共振成像（rest-fMRI）进行扫描。我们使用基于体素的形态计量学（VBM）探索对侧MTL的结构，并使用静息态功能连接（rs-FC）评估对侧半球的记忆网络。通过偏相关分析评估FC与认知功能之间的关联。
与健康对照者相比，两组患者均表现出：（1）使用基于感兴趣区域（ROI）的VBM分析，对侧MTL中有一大簇体素的灰质（GM）体积减少（簇水平p < 0.05，FDR校正）；（2）后海马体（pHPC）与后扣带回皮质（PCC）之间的半球内FC降低（p < 0.01，Bonferroni校正）。两组患者中，pHPC与PCC之间的半球内FC均与认知功能呈正相关。
使用多模态脑成像工具，我们发现单侧MTL胶质瘤患者对侧MTL存在结构和功能变化。这些发现表明，除了代偿性结构和功能适应外，单侧胶质瘤患者的对侧皮质可能存在结构和功能失代偿。我们的研究为胶质瘤患者对侧皮质的神经解剖和功能网络变化提供了更多见解。
