吗啡成瘾与氧化应激：硫氧还蛋白-1的潜在作用
Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1.
作者信息
Zeng Xian-Si, Geng Wen-Shuo, Wang Zhan-Qi, Jia Jin-Jing
机构信息
Key Laboratory of Tea Plant Biology of Henan Province, College of Life Sciences, Xinyang Normal University, Xinyang, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Sciences, Huzhou University, Huzhou, China.
出版信息
Front Pharmacol. 2020 Feb 21;11:82. doi: 10.3389/fphar.2020.00082. eCollection 2020.
Abstract
Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence. Numerous studies have demonstrated significant redox alteration in morphine dependence and addiction. Thioredoxin-1 (Trx-1) play important roles in controlling the cellular redox balance. In recent years, several recent studies have demonstrated that Trx-1 may be a promising novel therapeutic target for morphine addiction. In this article, we firstly review the redox alteration in morphine addiction. We also summarize the expression and the protective roles of Trx-1 in morphine dependence. We further highlight the protection of geranylgeranylacetone (GGA), a noncytotoxic pharmacological inducer of Trx-1, in morphine-induced conditioned place preference. In conclusion, Trx-1 may be very promising for clinical therapy of morphine addiction in the future.
摘要
长期使用吗啡治疗慢性疼痛会导致对其镇痛效果产生耐受性，甚至可能导致药物依赖。大量研究表明，吗啡依赖和成瘾过程中存在显著的氧化还原改变。硫氧还蛋白-1（Trx-1）在控制细胞氧化还原平衡中起重要作用。近年来，多项研究表明Trx-1可能是治疗吗啡成瘾的一个有前景的新型治疗靶点。在本文中，我们首先综述吗啡成瘾中的氧化还原改变。我们还总结了Trx-1在吗啡依赖中的表达及保护作用。我们进一步强调了香叶基香叶基丙酮（GGA），一种Trx-1的非细胞毒性药理学诱导剂，对吗啡诱导的条件性位置偏爱行为的保护作用。总之，Trx-1未来在吗啡成瘾的临床治疗中可能非常有前景。
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2
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Front Neurosci. 2019 Sep 20;13:1018. doi: 10.3389/fnins.2019.01018. eCollection 2019.
3
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6
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8
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