Activates Endoplasmic Reticulum Stress to Promote Crohn's Disease Development the Upregulation of CARD3 Expression.

There is increasing evidence that members of the gut microbiota, especially (), are associated with Crohn's disease (CD), but the specific mechanism by which promotes CD development is unclear. Here, we first examined the abundance of and its effects on CD disease activity and explored whether aggravated intestinal inflammation and promoted intestinal mucosal barrier damage and . Our data showed that was enriched in 41.21% of CD tissues from patients and was correlated with the clinical course, clinical activity, and refractory behavior of CD < 0.05). In addition, we found that infection is involved in activating the endoplasmic reticulum stress (ERS) pathway during CD development to promote intestinal mucosal barrier destruction. Mechanistically, targeted caspase activation and recruitment domain 3 (CARD3) to activate the ERS pathway and promote -mediated mucosal barrier damage and . Thus, coordinates a molecular network involving CARD3 and ERS to control the CD process. Measuring and targeting and its associated pathways will provide valuable insight into the prevention and treatment of CD.