Butkova T V, Kopylov A T, Stepanov A A, Malsagova K A, Kostyuk G P, Zakharova N V, Bravve L V, Sinicyna A A, Kaysheva A L
V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
State Healthcare Institution «Psychiatric Clinical Hospital 1 n. a. N.A. Alekseev of Healthcare Department of Moscow», Russia.
Data Brief. 2020 Feb 25;29:105338. doi: 10.1016/j.dib.2020.105338. eCollection 2020 Apr.
Schizophrenia is a complex chronic disease. The molecular determinants and neuropathology of schizophrenia are multifaceted; an important role in the pathogenesis is played by the dysregulation of molecular and epigenetic mechanisms. However, the molecular mechanisms of the development of the disease have not yet been studied. An important task is the accumulation and systematization of "OMICS"-knowledge of the molecular profiles (transcriptome, proteome, metabolome) of blood specific to pathology. Thereby the development and improvement of mass spectrometric methods for the detection of biological molecules has become increasingly important in biomedical research. In the field of applied problems in biomedical research, the most prevalent issue involves the identification of serological protein markers associated with the development of schizophrenia, which account for the diseases that cause the a life-shortening illness, disability, decreased of functioning and quality of life and wellbeing or health status. OMICS approaches are designed to detect genes (genomics), mRNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in a specific biological sample. We report the proteomic datasets on the serum samples from patients with schizophrenia (series "SCZ") and healthy volunteers (series "CNT"). Data were acquired using shotgun ultra-high resolution mass spectrometry.
精神分裂症是一种复杂的慢性疾病。精神分裂症的分子决定因素和神经病理学是多方面的；分子和表观遗传机制的失调在发病机制中起重要作用。然而，该疾病发展的分子机制尚未得到研究。一项重要任务是积累和系统化针对该病理的血液分子谱（转录组、蛋白质组、代谢组）的“组学”知识。因此，用于检测生物分子的质谱方法的开发和改进在生物医学研究中变得越来越重要。在生物医学研究的应用问题领域，最普遍的问题涉及鉴定与精神分裂症发展相关的血清学蛋白质标志物，精神分裂症是导致缩短寿命、残疾、功能和生活质量及幸福感或健康状况下降的疾病。组学方法旨在检测特定生物样本中的基因（基因组学）、mRNA（转录组学）、蛋白质（蛋白质组学）和代谢物（代谢组学）。我们报告了精神分裂症患者（“SCZ”系列）和健康志愿者（“CNT”系列）血清样本的蛋白质组数据集。数据通过鸟枪法超高分辨率质谱获得。
