Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland.
Department of Neurology, Faculty of Medicine, Medical University of Warsaw, Bielański Hospital, Warsaw, Poland.
Endokrynol Pol. 2020;71(2):109-115. doi: 10.5603/EP.a2020.0008. Epub 2020 Mar 10.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adipokines, secreted by adipose tissue, link the metabolism and immune system.
We aimed to assess plasma levels of selected adipokines in newly diagnosed, treatment-naïve individuals with multiple sclerosis. Our group comprised 58 individuals (31 MS patients and 27 controls, matched for age and BMI) without diabetes, hypertension, or dyslipidaemia. Circulating adiponectin and all adiponectin fractions, visfatin, and omentin concentrations were measured. Metabolic parameters were also assessed.
In MS individuals we observed the following results: higher concentrations of visfatin, lower levels of omentin, and no differences in adiponectin array. There were also correlations between some adipokines and metabolic parameters. After adjustment to BMI, a significant decrease in total adiponectin, high-molecular weight (HMW) adiponectin and omentin, and an increase in medium-molecular-weight (MMW) adiponectin were observed in the group of MS patients when compared to those of the controls.
Our results indicate that adiponectin with its fractions, visfatin, and omentin cannot be considered as causative factors in the early phase of multiple sclerosis. However, the potential role of adipokines in MS is possible because they might be involved in the pathogenesis of MS, regarded as an autoimmune disorder.
多发性硬化症（MS）是一种中枢神经系统自身免疫性疾病。确切病因尚不清楚。然而，遗传和环境因素被认为与 MS 的发病机制有关。不当的饮食导致肥胖和代谢综合征，也可能导致这种疾病。脂肪细胞因子由脂肪组织分泌，将代谢和免疫系统联系起来。
我们旨在评估新诊断、未经治疗的多发性硬化症患者的血浆中选定脂肪细胞因子的水平。我们的研究组包括 58 名个体（31 名 MS 患者和 27 名年龄和 BMI 匹配的对照组），无糖尿病、高血压或血脂异常。检测了循环脂联素和所有脂联素片段、内脏素和网膜素的浓度。还评估了代谢参数。
在 MS 患者中我们观察到以下结果：内脏素浓度升高，网膜素水平降低，脂联素无差异。一些脂肪细胞因子与代谢参数之间也存在相关性。调整 BMI 后，与对照组相比，MS 患者的总脂联素、高分子量（HMW）脂联素和网膜素显著降低，中分子量（MMW）脂联素升高。
我们的结果表明，脂联素及其片段、内脏素和网膜素不能被认为是多发性硬化症早期的致病因素。然而，脂肪细胞因子在 MS 中的潜在作用是可能的，因为它们可能参与了多发性硬化症的发病机制，被认为是一种自身免疫性疾病。
