Sawicka-Gutaj Nadia, Zybek-Kocik Ariadna, Kloska Michał, Ziółkowska Paulina, Czarnywojtek Agata, Sowiński Jerzy, Mańkowska-Wierzbicka Dorota, Ruchała Marek
Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Lehigh Valley Health Network, Department of Medicine, Lehigh Valley Hospital - Cedar Crest, Allentown, USA.
Endocr Connect. 2021 Apr 26;10(4):462-470. doi: 10.1530/EC-21-0059.
Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations positively correlated with total fat mass (r = 0.19, P = 0.01) and insulin concentrations (r = 0.17, P = 0.018). In conclusion, restoration of thyroid function is not associated with beneficial changes in body composition, especially among hyperthyroid females.
甲状腺功能失调对身体代谢有已知影响，然而，关于甲状腺功能恢复后的代谢结果的数据有限。因此，本研究的目的是调查甲状腺功能恢复正常对血清内脂素的影响，及其与胰岛素抵抗和身体成分的关联。这是一项连续入组的观察性研究。49名甲状腺功能亢进女性（中位年龄34岁）和44名甲状腺功能减退女性（中位年龄46岁）完成了研究。在治疗前后评估实验室参数和身体成分分析。在甲状腺功能亢进组中，内脂素浓度升高（P < 0.0001），而血糖浓度降低（P < 0.0001）。治疗期间全身质量以及躯干和四肢的脂肪质量显著增加。在甲状腺功能减退组中，躯干和四肢的脂肪和肌肉质量减少导致体重显著下降。血清内脂素浓度与总脂肪质量（r = 0.19，P = 0.01）和胰岛素浓度（r = 0.17，P = 0.018）呈正相关。总之，甲状腺功能恢复与身体成分的有益变化无关，尤其是在甲状腺功能亢进女性中。
