Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Neuron. 2020 May 20;106(4):579-588.e3. doi: 10.1016/j.neuron.2020.02.012. Epub 2020 Mar 9.
The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway between the inferior frontal gyrus and subthalamic nucleus is hypothesized to mediate movement inhibition, but there is limited evidence for this in humans. We recorded high spatial and temporal resolution field potentials from both the inferior frontal gyrus and subthalamic nucleus in 21 subjects. Cortical potentials evoked by subthalamic stimulation revealed short latency events indicative of monosynaptic connectivity between the inferior frontal gyrus and ventral subthalamic nucleus. During a stop signal task, stopping-related potentials in the cortex preceded stopping-related activity in the subthalamic nucleus, and synchronization between these task-evoked potentials predicted the stop signal reaction time. Thus, we show that a prefrontal-subthalamic hyperdirect pathway is present in humans and mediates rapid stopping. These findings may inform therapies to treat disorders featuring perturbed movement inhibition.
动态改变运动输出的能力，例如停止已启动的反应，是人类行为的一个重要方面。下额前回和丘脑底核之间的超直接通路被假设介导运动抑制，但在人类中对此的证据有限。我们在 21 名受试者中同时记录了下额前回和丘脑底核的高空间和时间分辨率场电位。丘脑底核刺激诱发的皮质电位显示出短潜伏期事件，表明下额前回和腹侧丘脑底核之间存在单突触连接。在停止信号任务中，皮质中的停止相关电位先于丘脑底核中的停止相关活动，并且这些任务诱发的电位之间的同步性预测了停止信号反应时间。因此，我们表明，人类存在前额叶-丘脑底核超直接通路，并介导快速停止。这些发现可能为治疗以运动抑制障碍为特征的疾病提供信息。
