Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada (LHYEDEC), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina; Facultad de Ciencias Veterinarias, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
Laboratorio de Patología Especial Veterinaria Dr. Bernardo Epstein, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
Res Vet Sci. 2020 Jun;130:93-97. doi: 10.1016/j.rvsc.2020.03.006. Epub 2020 Mar 3.
Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis process could be the basis for the development of novel molecular mechanism-based antitumour treatments for CP and CSCC canine patients. Recent evidence suggests that the development and progression of CP and CSCC involve the dysregulated activation of the Hippo signalling pathway effector YAP. Thus, in the present study, we evaluated the immunohistochemical expression pattern of YAP in sections of tissue microarrays constructed from canine samples of normal epidermis, CP, preneoplastic epidermis, and CSCC. In samples of CP, preneoplastic epidermis, and CSCC, YAP expression was significantly increased relative to normal epidermis. This emerging evidence suggests that the dysregulated activity of the Hippo signalling pathway effector YAP represents a frequent event during canine epidermal tumourigenesis, pointing to this protein as a potential therapeutic target for the treatment of CP and CSCC in dogs.
皮肤乳头瘤（CP）和皮肤鳞状细胞癌（CSCC）是犬中常见的表皮肿瘤。在这方面，研究表皮肿瘤发生过程中信号分子的失调活性可能为 CP 和 CSCC 犬患者的新型基于分子机制的抗肿瘤治疗提供基础。最近的证据表明，CP 和 CSCC 的发展和进展涉及 Hippo 信号通路效应物 YAP 的失调激活。因此，在本研究中，我们评估了组织微阵列中犬正常表皮、CP、癌前表皮和 CSCC 组织样本中 YAP 的免疫组织化学表达模式。在 CP、癌前表皮和 CSCC 样本中，YAP 的表达相对于正常表皮显著增加。这一新兴证据表明，Hippo 信号通路效应物 YAP 的失调活性是犬表皮肿瘤发生过程中的常见事件，表明该蛋白可能成为治疗 CP 和 CSCC 的潜在治疗靶点。
