Brogna Claudia, Luigetti Marco, Norcia Giulia, Scalise Roberta, Ferrantini Gloria, Berti Beatrice, Romeo Domenico M, Manna Raffaele, Mercuri Eugenio, Pane Marika
Pediatric Neurology and Nemo Clinical Centre, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Roma 00168, Italy.
Pediatric Neuropsichiatric Unit, ASL, Avellino 83100, Italy.
Brain Sci. 2020 Mar 7;10(3):156. doi: 10.3390/brainsci10030156.
We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.
我们报告了一名9岁女孩的临床病例，该女孩表现为进行性运动神经病，通过数字化神经传导/肌电图检测发现F波记录延迟增加得以揭示。由于使用稀释的蝰蛇毒时间（dRVVT）检测到狼疮抗凝物（LAC）阳性转变为持续性血清抗心磷脂免疫球蛋白G（IgG）阳性，怀疑可能存在非血栓性抗磷脂抗体（aPL）相关的临床表现，并开始进行静脉注射免疫球蛋白治疗（IVIG）。IVIG治疗耐受性良好，在第三次IVIG输注后运动障碍完全缓解。我们的研究结果表明，对于快速出现进行性神经体征的儿童，检查抗磷脂抗体可能有用，以便在治疗儿童aPL神经系统疾病中有益地使用IVIG。
