端粒长度能否预测骨骼健康？当前证据综述。
Can telomere length predict bone health? A review of current evidence.
机构信息
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Bosn J Basic Med Sci. 2020 Nov 2;20(4):423-429. doi: 10.17305/bjbms.2020.4664.
Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has been proposed as an indicator for biological aging, but its relationship with age-related osteoporosis is ambiguous. We summarize the current evidence on the relationship between telomere length and bone health in experimental and epidemiological studies, which serve as a scientific reference for the development of novel diagnostic markers of osteoporosis or novel therapeutics targeting telomere and telomerase of bone cells to treat osteoporosis.
端粒是位于染色体末端的重复 DNA 序列，可作为细胞分裂过程中染色体降解的保护屏障。每次细胞分裂大约会丢失 50-200 个核苷酸碱基，而端粒酶会添加新的重复核苷酸，从而维持端粒。端粒缩短被认为是生物衰老的一个指标，但它与与年龄相关的骨质疏松症的关系尚不清楚。我们总结了实验和流行病学研究中关于端粒长度与骨骼健康之间关系的现有证据，为骨质疏松症的新型诊断标志物或针对骨细胞端粒和端粒酶的新型治疗方法的开发提供了科学参考。
Zotero 插件