Mansour Alaa, Romani Maya, Acharya Anirudh Balakrishna, Rahman Betul, Verron Elise, Badran Zahi
Periodontology Unit, College of Dental Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Department of Family Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107, Lebanon.
Pharmaceutics. 2023 Feb 18;15(2):695. doi: 10.3390/pharmaceutics15020695.
Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder their benefits. Moreover, advances in biotechnology resulted in the development of a new generation of molecules with a short half-life that necessitates frequent administration. In this context, controlled release systems are required to enhance treatment efficacy and improve patient compliance. Innovative drug delivery systems are promising tools that protect therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. The present review provides an overview of different approaches used for drug delivery.
现代药物发现方法催生了具有显著治疗潜力的新型药物。然而，它们的性质，如溶解度和与给药相关的挑战，可能会阻碍其疗效。此外，生物技术的进步导致了新一代半衰期短的分子的开发，这就需要频繁给药。在这种情况下，需要控释系统来提高治疗效果并改善患者的依从性。创新的药物递送系统是很有前景的工具，可保护治疗性蛋白质和肽免受蛋白水解降解，并实现可控递送。本综述概述了用于药物递送的不同方法。
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