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维生素 E 醋酸酯热解蒸气电子烟释放肺毒性丙烯醛的可能性。

Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate.

机构信息

Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland

出版信息

Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6349-6355. doi: 10.1073/pnas.1920925117. Epub 2020 Mar 10.

DOI:10.1073/pnas.1920925117
PMID:32156732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7104367/
Abstract

A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using e-cigarette/vaping products. Additionally, the pyrolysis of vitamin E acetate also produces carcinogen alkenes and benzene for which the negative long-term medical effects are well recognized. As temperatures reached in vaping devices can be equivalent to a laboratory pyrolysis apparatus, the potential for unexpected chemistries to take place on individual components within a vape mixture is high. Educational programs to inform of the danger are now required, as public perception has grown that vaping is not harmful.

摘要

一项综合分析、理论和实验研究表明,吸食维生素 E 醋酸酯有可能产生毒性极高的乙烯酮气体,这可能是导致与使用电子烟/蒸气产品相关的肺部损伤病例激增的一个因素。此外,维生素 E 醋酸酯的热解还会产生致癌烯烃和苯,其长期的负面影响是众所周知的。由于电子烟设备中的温度可能相当于实验室热解设备,因此在蒸气混合物的个别成分中发生意外化学反应的可能性很高。现在需要开展教育计划,告知其危害,因为公众的看法已经发生变化,认为蒸气产品没有危害。

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