Department of Plastic, Hand- and Reconstructive Surgery, University Medical Center, Regensburg, Germany.
Department of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Aesthetic Plast Surg. 2020 Jun;44(3):855-861. doi: 10.1007/s00266-020-01666-6. Epub 2020 Mar 10.
Multiple symmetric lipomatosis (MSL) (syn.: Launois-Bensaude Syndrome, benign symmetric lipomatosis) is a rare disease of fatty tissue. The pathophysiology of MSL still remains unclear, although several approaches have been described in order to understand it. Beside morphological characteristics and some molecular cell biological approaches, little is known about the histological and immunohistochemical characterization of adipose tissue from patients with MSL.
From the 45 patients with MSL in our database, 10 were included in the study. Fat tissue samples were collected from affected and unaffected areas. The forearm served as a control area as this area is not affected in MSL. The specimens were analyzed after selected stainings were taken (hematoxylin-eosin = HE, Elastica van Gieson, Ladewig, CD200, CIDEA, myf5, p107, Prdm16, Sca-1, syndecan, UCP1, MAC387, Glut4).
In patients suffering from MSL, no macroscopic or microscopic morphological difference could be found between affected and unaffected adipose tissue in HE stainings. The majority of samples showed positivity for UCP1 (9/10 clinically affected tissues, 7/10 clinically unaffected tissues) and CD200.
Marker profiles support the hypothesis that affected adipose tissue derives from brown or beige adipose tissue rather than from white fat.
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多发性对称性脂肪瘤病（MSL）（同义词：Launois-Bensaude 综合征，良性对称性脂肪瘤病）是一种罕见的脂肪组织疾病。尽管已经描述了几种方法来理解它，但 MSL 的病理生理学仍然不清楚。除了形态学特征和一些分子细胞生物学方法外，对于 MSL 患者脂肪组织的组织学和免疫组织化学特征知之甚少。
从我们的数据库中 45 名 MSL 患者中，选取了 10 名患者纳入研究。从受影响和未受影响的区域采集脂肪组织样本。前臂作为对照区域，因为 MSL 不会影响这个区域。在进行了特定染色（苏木精-伊红染色=HE、弹力纤维 van Gieson、Ladewig、CD200、CIDEA、myf5、p107、Prdm16、Sca-1、syndecan、UCP1、MAC387、Glut4）后，对标本进行了分析。
在患有 MSL 的患者中，在 HE 染色中，受影响和未受影响的脂肪组织之间没有发现肉眼或显微镜下的形态学差异。大多数样本对 UCP1（9/10 例临床受影响的组织，7/10 例临床未受影响的组织）和 CD200 呈阳性。
标记物谱支持受影响的脂肪组织来源于棕色或米色脂肪组织而非白色脂肪的假说。
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