Li Shuo, Xiao Yiding, Wang Yang, Bai Ming, Du Fengzhou, Zhang Hailin
Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jan 15;16:103-110. doi: 10.2147/CCID.S368273. eCollection 2023.
Madelung's disease (MD) is a rare condition of massive deposits of fat accumulations between superficial and deep fascia at typical locations. There is an absence of systematic studies related to MD in the Chinese cohort. Thus, the objective of the study was to investigate the clinical features of the MD cases in our institution and to explore the clinical variables associated with postoperative recurrence.
We retrospectively analyzed the clinical information of 21 individuals with MD from 2013 to 2021 enrolled in our institution. The paired -test and test were, respectively, used to determine the difference between continuous and classified variables. The univariate Kaplan-Meier analysis by log-rank and multivariate stepwise Cox regression analysis were used to explore variables possibly associated with postoperative recurrence in MD individuals.
In the current study, 90.48% of the studied patients were male with a mean age of 48.76 years old. About 61.90% exhibited type I MD. MD patients who experienced postoperative recurrence had a higher age, BMI, incidence of chronic complications, and prevalence of alcoholism than the other MD patients without recurrence (P < 0.05). The univariate Kaplan-Meier analysis by log-rank identified that age, BMI, alcoholism, and comorbidities were influencing factors related with postoperative recurrence (P < 0.05).
Demographic characteristics of the 21 studied Chinese cases with MD were generally in accordance with previously published data of other foreign populations. The factors possibly influencing the postoperative recurrence for patients with MD were age, BMI, alcoholism, and a combination of comorbidities. This is the first time that a summarization of clinical characteristics and postoperative recurrence variables of Chinese patients with MD has been reported.
马德隆氏病（MD）是一种罕见疾病，在典型部位的浅筋膜和深筋膜之间有大量脂肪堆积。在中国人群中，尚未有关于MD的系统性研究。因此，本研究的目的是调查我院MD患者的临床特征，并探讨与术后复发相关的临床变量。
我们回顾性分析了2013年至2021年在我院就诊的21例MD患者的临床信息。分别采用配对t检验和检验来确定连续变量和分类变量之间的差异。采用单因素Kaplan-Meier对数秩分析和多因素逐步Cox回归分析，以探讨可能与MD患者术后复发相关的变量。
在本研究中，90.48%的患者为男性，平均年龄为48.76岁。约61.90%的患者表现为I型MD。与未复发的其他MD患者相比，术后复发的MD患者年龄更大、体重指数更高、慢性并发症发生率更高、酗酒患病率更高（P<0.05）。单因素Kaplan-Meier对数秩分析确定年龄、体重指数、酗酒和合并症是与术后复发相关的影响因素（P<0.05）。
21例中国MD患者的人口统计学特征总体上与先前发表的其他外国人群数据一致。可能影响MD患者术后复发的因素是年龄、体重指数、酗酒和合并症。这是首次报道中国MD患者的临床特征和术后复发变量的总结。
