Universidade de Pernambuco, Recife, Brazil.
Universidade Federal de Pernambuco, Recife, Brazil.
Am J Trop Med Hyg. 2020 May;102(5):982-984. doi: 10.4269/ajtmh.19-0753.
The genitourinary tract was recently identified as a potential site of complications related to the congenital Zika syndrome (CZS). We provide the first report of a series of cryptorchidism cases in 3-year-old children with Zika-related microcephaly who underwent consultations between October 2018 and April 2019 as part of the follow-up of the children cohort of the Microcephaly Epidemic Research Group, Pernambuco, Brazil. Of the 22 males examined, eight (36.4%) presented with cryptorchidism. Among 14 undescended testis cases, 11 (78.6%) could be palpated in the inguinal region. Seven of the eight children had severe microcephaly. Conventional risk factors for cryptorchidism were relatively infrequent in these children. We hypothesize that cryptorchidism is an additional manifestation of CZS present in children with severe microcephaly. As in our cases, for most of the children, the testes were located in the inguinal region, and the possible mechanisms for cryptorchidism were gubernaculum disturbance or cremasteric abnormality.
最近有研究发现，泌尿生殖系统可能是与先天性寨卡综合征（CZS）相关的并发症的潜在部位。我们首次报道了巴西伯南布哥州微头畸形流行研究小组对 2018 年 10 月至 2019 年 4 月间就诊的 3 岁患有寨卡相关小头畸形的儿童进行的一系列隐睾病例的随访结果。在接受检查的 22 名男性中，有 8 名（36.4%）存在隐睾症。在 14 例未降睾丸病例中，11 例（78.6%）可在腹股沟区域触及。这 8 名儿童中有 7 名患有严重的小头畸形。对于这些儿童来说，隐睾症的常规风险因素相对较少。我们假设隐睾症是严重小头畸形患儿中 CZS 的另一种表现。与我们的病例一样，对于大多数儿童来说，睾丸位于腹股沟区域，隐睾症的可能机制是提睾肌紊乱或提睾肌异常。
