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埃塞俄比亚提格雷西北部结核病六年趋势分析;2019年:一项回顾性研究。

Six Years Trend Analysis of Tuberculosis in Northwestern Tigrai, Ethiopia; 2019: A Retrospective Study.

作者信息

Negash Hadush, Legese Haftom, Adhanom Gebre, Mardu Fitsum, Tesfay Kebede, Gebreslasie Gebremeskel Senait, Berhe Brhane

机构信息

Unit of Medical Microbiology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Tigrai, Ethiopia.

Unit of Medical Parasitology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Tigrai, Ethiopia.

出版信息

Infect Drug Resist. 2020 Feb 24;13:643-649. doi: 10.2147/IDR.S239717. eCollection 2020.

Abstract

BACKGROUND

Ethiopia is one of the 22 high tuberculosis burden countries. In our country. there are limited published data to show the trend analysis of tuberculosis. Hence, we designed this trend analysis to fill the information gap in our study area. Institutional based retrospective cross-sectional study was employed from 2013 to 2018 to determine the trend analysis of tuberculosis among tuberculosis presumptive clients in Northwestern Tigrai. We have used a standard checklist to extract the data. There were some missing data from the logbooks which are then excluded from the analysis.

RESULTS

A total of 7793 tuberculosis presumptive clients were requested for laboratory diagnosis of which about 7639 results had a valid result for X-pert MTB/Rif assay. The overall detection rate of tuberculosis was found to be 9.9% (756/7639). Of the total tuberculosis cases, 8.7 % (66/756) were rifampicin-resistant. The trend of tuberculosis across the six years was fluctuating with a declining trend in the recent three years. HIV infection and being presumptive to drug resistance were associated with tuberculosis detection.

CONCLUSION

Although there was a cumulative declining trend of tuberculosis within the last six years, prevention and control strategies still need to be improved to achieve the stop tuberculosis strategy. To create a world free of tuberculosis, there should be quality service provision regarding tuberculosis case detection and treatment.

摘要

背景

埃塞俄比亚是22个结核病高负担国家之一。在我国,关于结核病趋势分析的已发表数据有限。因此,我们设计了这项趋势分析,以填补我们研究区域的信息空白。采用基于机构的回顾性横断面研究,对2013年至2018年提格雷西北部结核病疑似患者中的结核病趋势进行分析。我们使用标准清单提取数据。日志中有一些缺失数据,随后将其排除在分析之外。

结果

总共7793名结核病疑似患者被要求进行实验室诊断,其中约7639份Xpert MTB/Rif检测结果有效。结核病的总体检出率为9.9%(756/7639)。在所有结核病病例中,8.7%(66/756)对利福平耐药。六年内结核病的趋势呈波动状,最近三年呈下降趋势。艾滋病毒感染和疑似耐药与结核病检测相关。

结论

尽管过去六年结核病呈累计下降趋势,但仍需改进预防和控制策略以实现终止结核病战略。为创造一个无结核病的世界,应在结核病病例检测和治疗方面提供高质量服务。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c155/7047984/12c10435076b/IDR-13-643-g0001.jpg

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