Wakumoto Keiko, Yoshida Yuichi, Yamamoto Osamu
Division of Dermatology, Matsue Red Cross Hospital, Matsue 690-0886, Japan.
Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
Yonago Acta Med. 2020 Feb 20;63(1):92-94. doi: 10.33160/yam.2020.02.012. eCollection 2020 Feb.
We report a case of X-linked recessive ichthyosis with basal cell carcinoma. An 86-year-old man was referred to our department for evaluation of a 1-year history of an ulcer on his left leg. He had suffered from dry skin with scales on his entire body since childhood. Histopathological examination of the lower leg revealed intradermal proliferation of a solid nest of basaloid cells showing unclear palisading in the periphery. Marked hyperkeratosis and hypergranulosis were also seen in the adjacent dermis. Loss of the steroid sulfatase gene was found on chromosome X. Based on these finding, we made a diagnosis of X-linked recessive ichthyosis with basal cell carcinoma. To our knowledge, there has been no report of X-linked recessive ichthyosis with cutaneous malignancy. We discuss the risk of skin cancer in relation to ichthyosis.
我们报告一例伴有基底细胞癌的X连锁隐性鱼鳞病病例。一名86岁男性因左腿溃疡1年病史转诊至我科。他自童年起就患有全身皮肤干燥伴鳞屑。小腿组织病理学检查显示真皮内有一实性基底样细胞巢增生，周边栅栏状排列不清晰。相邻真皮还可见明显的角化过度和颗粒层增厚。在X染色体上发现类固醇硫酸酯酶基因缺失。基于这些发现，我们诊断为伴有基底细胞癌的X连锁隐性鱼鳞病。据我们所知，此前尚无伴有皮肤恶性肿瘤的X连锁隐性鱼鳞病的报道。我们讨论了鱼鳞病相关的皮肤癌风险。
