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[提取物名称]水醇提取物对高脂饮食诱导的大鼠肝脂肪变性的抗高血脂和抗氧化作用

Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of on the Hepatosteatosis Induced with High-Fat Diet in Rats.

作者信息

Pasavei Abdolmomen Ghaeni, Mohebbati Reza, Boroumand Nadia, Ghorbani Ahmad, Hosseini Azar, Jamshidi Shirin Taraz, Soukhtanloo Mohammad

机构信息

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Malays J Med Sci. 2020 Feb;27(1):57-69. doi: 10.21315/mjms2020.27.1.6. Epub 2020 Feb 27.

DOI:10.21315/mjms2020.27.1.6
PMID:32158345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7053549/
Abstract

INTRODUCTION

The aim of the current study is to evaluate the antihyperlipidemic and anti-oxidative effects of hydro-alcoholic extract of marjoram (HAEM) in rats fed with a high-fat diet (HFD).

METHODS

In the experimental study, the rats were randomly divided into four groups of five rats in each and fed with high-fat diet for 12 weeks as follows: One group (normal diet group) was fed with a standard diet, one group was fed with HFD, and two groups were fed with HFD and orally fed with 150 and 450 mg/kg/day HAEM. The serum samples and liver tissues were used for measuring the biochemical and oxidative parameters and histopathological studies. HFD induced hepatosteatosis in rats as evidenced by the altered liver enzymes activity, serum lipid profile and oxidative status.

RESULTS

Serum lipid profile (triglyceride, cholesterol and low-density lipoprotein) in rats fed with HFD + HAEM (150 and 450 mg/kg/day) was significantly decreased. Furthermore, the evaluation of oxidative stress showed a reduction of the malondialdehyde (MDA) level and an increase in ferric-reducing anti-oxidant power. Meanwhile, liver enzyme activities declined in response to HAEM.

CONCLUSION

Using the HAEM could be a future therapeutic agent in treating hepatosteatosis and reducing oxidative damages of HFD in the liver.

摘要

引言

本研究旨在评估马郁兰水醇提取物（HAEM）对高脂饮食（HFD）喂养大鼠的降血脂和抗氧化作用。

方法

在实验研究中，将大鼠随机分为四组，每组五只，按以下方式给予高脂饮食12周：一组（正常饮食组）给予标准饮食，一组给予高脂饮食，两组给予高脂饮食并分别口服150和450毫克/千克/天的HAEM。采集血清样本和肝脏组织用于测量生化和氧化参数以及进行组织病理学研究。高脂饮食导致大鼠肝脂肪变性，这可通过肝酶活性、血清脂质谱和氧化状态的改变得以证实。

结果

给予HFD + HAEM（150和450毫克/千克/天）的大鼠血清脂质谱（甘油三酯、胆固醇和低密度脂蛋白）显著降低。此外，氧化应激评估显示丙二醛（MDA）水平降低，铁还原抗氧化能力增强。同时，肝酶活性因HAEM而下降。

结论

使用HAEM可能成为未来治疗肝脂肪变性和减少高脂饮食对肝脏氧化损伤的治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/438c/7053549/2c651b37e3aa/06mjms27012020_oa3f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/438c/7053549/2c651b37e3aa/06mjms27012020_oa3f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/438c/7053549/3a504e481cbf/06mjms27012020_oa3f1.jpg
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