Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132 Genoa, Italy.
Nanoscopy and NIC@IIT, Istituto Italiano di Tecnologia, 16152 Genoa, Italy.
Molecules. 2022 Aug 8;27(15):5043. doi: 10.3390/molecules27155043.
Numerous plants, plant extracts, and plant-derived compounds are being explored for their beneficial effects against overweight and liver diseases. Obesity is associated with the increased prevalence of non-alcoholic fatty liver disease (NAFLD), becoming the most common liver disease in Western countries. Obesity and NAFLD are closely associated with many other metabolic alternations such as insulin resistance, diabetes mellitus, and cardiovascular diseases. Many herbs of the Lamiaceae family are widely employed as food and spices in the Mediterranean area, but also in folk medicine, and their use for the management of metabolic disorders is well documented. Hereby, we summarized the scientific results of the medicinal and nutraceutical potential of plants from the Lamiaceae family for prevention and mitigation of overweight and fatty liver. The evidence indicates that Lamiaceae plants may be a cost-effective source of nutraceuticals and/or phytochemicals to be used in the management of metabolic-related conditions such as obesity and NAFLD. PubMed, Google Scholar, Scopus, and SciFinder were accessed to collect data on traditional medicinal plants, compounds derived from plants, their reported anti-obesity mechanisms, and therapeutic targets.
许多植物、植物提取物和植物衍生化合物因其对超重和肝脏疾病的有益作用而受到研究。肥胖与非酒精性脂肪性肝病（NAFLD）的患病率增加有关，已成为西方国家最常见的肝脏疾病。肥胖和 NAFLD 与许多其他代谢变化密切相关，如胰岛素抵抗、糖尿病和心血管疾病。许多唇形科植物作为地中海地区的食物和香料广泛使用，也在民间医学中使用，它们在代谢紊乱的管理中的应用已有充分的记录。在此，我们总结了唇形科植物在预防和缓解超重和脂肪肝方面的药用和营养潜力的科学研究成果。有证据表明，唇形科植物可能是一种具有成本效益的营养保健品和/或植物化学物质来源，可用于管理肥胖和 NAFLD 等与代谢相关的疾病。通过 PubMed、Google Scholar、Scopus 和 SciFinder 检索收集有关传统药用植物、植物衍生化合物、其报道的抗肥胖机制和治疗靶点的数据。
