Giacomelli Luca, Moglia Alessandra, Losa Gianedoardo, Quaglino Pietro
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Vivendo Pharma GmbH, Cham, Switzerland.
Drugs Context. 2020 Jan 9;9. doi: 10.7573/dic.2019-10-1. eCollection 2020.
The skin is the largest organ in the human body; beyond its regulatory and sensory roles, it is meant to protect and act like a barrier against foreign matter. Products intended to restore the skin health should reintegrate the structure of the stratum corneum in which the corneocytes are surrounded by the intercellular lipid lamellae that maintain both corneum integrity and skin permeability barrier. Capilen is a specific liposomal formulation based on a technology through which highly concentrated fresh plant extracts are conveyed into a jelly-like liposomal vehicle and combined with plant-derived omega-3, -6, -7, and -9 fatty acids, phospholipids, and precursors of ceramides. Its components have been widely investigated and produced clinical benefits in atopic dermatitis, bedsores, scars, inflammatory lesions of the skin, and generally whenever signs of xerosis cutis were present. Liposomes contribute to restore the surface lipid layer of the skin and to deliver substances in the activity site. This liposomal cream was proven to limit and delay the occurrence of radiodermatitis in breast cancer patients, and as an add-on provided complete healing of bedsore lesions in geriatric subjects.
皮肤是人体最大的器官；除了其调节和感觉功能外，它还旨在起到保护作用，像一道屏障抵御外来物质。旨在恢复皮肤健康的产品应重塑角质层结构，其中角质形成细胞被细胞间脂质片层包围，这些脂质片层维持着角质层的完整性和皮肤渗透屏障。卡皮林（Capilen）是一种基于特定技术的脂质体制剂，通过该技术，高浓缩的新鲜植物提取物被输送到一种果冻状脂质体载体中，并与植物来源的ω-3、-6、-7和-9脂肪酸、磷脂以及神经酰胺前体相结合。其成分已得到广泛研究，并在特应性皮炎、褥疮、疤痕、皮肤炎症性病变以及一般出现皮肤干燥迹象的情况下产生了临床益处。脂质体有助于恢复皮肤的表面脂质层，并将物质输送到活性部位。这种脂质体乳膏已被证明可限制和延缓乳腺癌患者放射性皮炎的发生，并且作为附加治疗手段可使老年受试者的褥疮损伤完全愈合。
