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膀胱平滑肌瘤合并胸膜孤立性纤维瘤

Bladder Leiomyoma with Synchronous Solitary Fibrous Tumor of the Pleura.

作者信息

Mavridis Charalampos, Georgiadis George, Lagoudaki Eleni D, Skamagkas Iordanis, Heretis Ioannis, Koutsopoulos Anastasios V, Mamoulakis Charalampos

机构信息

Department of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.

Department of Pathology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.

出版信息

Case Rep Urol. 2020 Feb 25;2020:3717506. doi: 10.1155/2020/3717506. eCollection 2020.

Abstract

Bladder leiomyomas (BLs) are extremely rare benign tumors of mesenchymal origin. The exact pathophysiological mechanisms that lead to their appearance remain unclear including hormonal disorders, chromosomal abnormalities, and fetal remnants in the bladder. They usually remain asymptomatic for a long period of time. Solitary fibrous tumors (SFTs) are also rare neoplasms of mesenchymal origin with malignant potential usually affecting the pleura. The pathogenesis of SFTs remains unclear. We report the case of a 28-year-old male presenting with SFT of the pleura and synchronous BL. The patient presented with persistent cough as a sole symptom. Computed tomography (CT) of the thorax revealed a pleural mass, which was surgically removed and proved to be a SFT. At an early follow-up, abdominal CT scan revealed a bladder wall mass that proved to be a BL. This is the first report of BL with synchronous SFT of the pleura. Synchronous BLs and SFTs may be incidental, but the coexistence of two mesenchymal tumors at different sites, in a young patient, may raise the suspicion of a new clinical syndrome that warrants further investigation.

摘要

膀胱平滑肌瘤(BLs)是极为罕见的间叶源性良性肿瘤。导致其出现的确切病理生理机制仍不清楚,包括激素紊乱、染色体异常以及膀胱内的胎儿残余组织。它们通常在很长一段时间内保持无症状。孤立性纤维瘤(SFTs)也是罕见的具有恶性潜能的间叶源性肿瘤,通常累及胸膜。SFTs的发病机制尚不清楚。我们报告一例28岁男性,患有胸膜SFT并同时患有BL。该患者仅以持续性咳嗽为唯一症状。胸部计算机断层扫描(CT)显示一个胸膜肿块,手术切除后证实为SFT。在早期随访中,腹部CT扫描显示一个膀胱壁肿块,证实为BL。这是胸膜SFT与BL同时存在的首例报告。同步性BLs和SFTs可能是偶然的,但在一名年轻患者中,两个不同部位的间叶肿瘤共存,可能会引发对一种新的临床综合征的怀疑,值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/7061107/d42e27d33c30/CRIU2020-3717506.001.jpg

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