Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu, China.
State-province Joint Engineering Laboratory of Spatial Information Technology of High-Speed Rail Safety, Chengdu, China.
Luminescence. 2020 Sep;35(6):808-820. doi: 10.1002/bio.3796. Epub 2020 Mar 11.
On-site identification and quantification of chemicals is critical for promoting food safety, human health, homeland security risk assessment, and disease diagnosis. Surface-enhanced Raman spectroscopy (SERS) has been widely considered as a promising method for on-site analysis due to the advantages of nondestructive, abundant molecular information, and outstanding sensitivity. However, SERS for on-site application has been restricted not only by the cost, performance, and portability of portable Raman instruments, but also by the sampling ability and signal enhancing performance of the SERS substrates. In recent years, the performance of SERS for on-site analysis has been improved through portable Raman instruments, SERS substrates, and other combined technologies. In this review, popular commercial portable Raman spectrometers and the related technologies for on-site analysis are compared. In addition, different types of SERS substrates for on-site application are summarized. SERS combined with other technologies, such as electrochemical and microfluidics are also presented. The future perspective of SERS for on-site analysis is also discussed.
现场鉴定和定量化学物质对于促进食品安全、人类健康、国土安全风险评估和疾病诊断至关重要。表面增强拉曼光谱（SERS）由于具有非破坏性、丰富的分子信息和出色的灵敏度等优点，已被广泛认为是一种很有前途的现场分析方法。然而，SERS 的现场应用不仅受到便携式拉曼仪器的成本、性能和便携性的限制，还受到 SERS 基底的采样能力和信号增强性能的限制。近年来，通过便携式拉曼仪器、SERS 基底和其他组合技术，提高了 SERS 现场分析的性能。在这篇综述中，比较了流行的商业便携式拉曼光谱仪和现场分析的相关技术。此外，还总结了不同类型的 SERS 基底用于现场应用。还介绍了 SERS 与电化学和微流控等其他技术的结合。还讨论了 SERS 现场分析的未来展望。
