Chen Ming, Zhang Xiaoyan, Liu Junkai, Liu Feng, Zhang Ruoyao, Wei Peifa, Feng Haitao, Tu Mei, Qin Anjun, Lam Jacky W Y, Ding Dan, Tang Ben Zhong
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
ACS Nano. 2020 Apr 28;14(4):4265-4275. doi: 10.1021/acsnano.9b09625. Epub 2020 Mar 17.
Development of highly effective approaches to desirable photothermal conversion agents is particularly valuable. Herein, we report a concept, namely, bond stretching vibration-induced photothermy, that serves as a mechanism to construct advanced photothermal conversion agents. As a proof-of-concept, two compounds (DCP-TPA and DCP-PTPA) with donor-acceptor (D-A) structures were synthesized. The bond stretching vibration of the pyrazine-containing unit in these molecules is vigorous and insensitive to the external environmental restraint, which efficiently transforms the absorbed photons to dark-state heat energy. The nanoparticles (NPs) of DCP-TPA and DCP-PTPA show rather high photothermal conversion efficiency (52% and 59%) and stronger photoacoustic (PA) signal than commercial methylene blue and reported high-performance semiconducting polymer nanoparticles. The DCP-PTPA NPs perform better than DCP-TPA NPs in terms of photothermal conversion, PA signal production, and PA tumor imaging because of the increased bond stretching vibration in the former molecule.
开发高效的理想光热转换剂方法具有特别重要的价值。在此，我们报告了一种概念，即键拉伸振动诱导光热效应，它作为构建先进光热转换剂的一种机制。作为概念验证，合成了两种具有供体-受体（D-A）结构的化合物（DCP-TPA和DCP-PTPA）。这些分子中含吡嗪单元的键拉伸振动强烈且对外部环境限制不敏感，能有效地将吸收的光子转化为暗态热能。DCP-TPA和DCP-PTPA的纳米颗粒（NPs）显示出相当高的光热转换效率（分别为52%和59%），并且比商业亚甲蓝和已报道的高性能半导体聚合物纳米颗粒具有更强的光声（PA）信号。由于前一种分子中键拉伸振动增加，DCP-PTPA NPs在光热转换、PA信号产生和PA肿瘤成像方面比DCP-TPA NPs表现更好。
