炎症在糖尿病眼中视网膜微循环中的作用：房水闪辉与微血管发现的相关性。
Role of Inflammation in Retinal Microcirculation in Diabetic Eyes: Correlation between Aqueous Flare and Microvascular Findings.
机构信息
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey,
出版信息
Ophthalmologica. 2020;243(5):391-398. doi: 10.1159/000507089. Epub 2020 Mar 11.
PURPOSE
To investigate the correlation between aqueous flare and macular microvascular status assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus.
METHODS
A cross-sectional study was conducted on 52 diabetic patients with nonproliferative retinopathy, 44 diabetic patients without retinopathy, and 20 nondiabetic age-matched controls. Spectral domain OCT, OCTA, and laser flare-cell meter were performed.
RESULTS
Compared to eyes without retinopathy, eyes with retinopathy had higher flare intensity (p = 0.024), enlarged capillary nonperfusion area (p < 0.001), and enlarged foveal avascular zone (p < 0.001). There was a significant correlation between flare intensity and capillary nonperfusion areas (p < 0.001, r = 0.511) and superficial capillary density (p = 0.005, r = -0.388) in diabetic eyes with retinopathy.
CONCLUSION
The results demonstrated a positive correlation between aqueous flare levels, an indicator of intraocular inflammation, and microvascular damage demonstrated by OCTA in the early stages of diabetic retinopathy (DR). This finding supports the role of inflammation in the pathogenesis of DR.
目的
探讨糖尿病患者眼内液闪辉与光相干断层扫描血管造影（OCTA）评估的黄斑微血管状态的相关性。
方法
对 52 例非增殖性视网膜病变的糖尿病患者、44 例无视网膜病变的糖尿病患者和 20 例年龄匹配的非糖尿病对照者进行了横断面研究。进行了频域 OCT、OCTA 和激光闪辉细胞计检查。
结果
与无视网膜病变的眼相比，有视网膜病变的眼的闪辉强度更高（p = 0.024），毛细血管无灌注面积增大（p < 0.001），中心凹无血管区增大（p < 0.001）。有视网膜病变的糖尿病眼中，闪辉强度与毛细血管无灌注区（p < 0.001，r = 0.511）和浅层毛细血管密度（p = 0.005，r = -0.388）呈显著正相关。
结论
这些发现支持炎症在糖尿病性视网膜病变发病机制中的作用，结果表明，在糖尿病性视网膜病变（DR）的早期阶段，眼内液闪辉水平（眼内炎症的一个指标）与 OCTA 评估的微血管损伤之间存在正相关。
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