Centre for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603, Kuala Lumpur, Malaysia.
Mimia Sdn. Bhd., Selangor, Malaysia.
Biogerontology. 2020 Jun;21(3):293-310. doi: 10.1007/s10522-020-09865-z. Epub 2020 Mar 11.
The deterioration of the skin morphology and physiology is the first and earliest obvious harbinger of the aging process which is progressively manifested with increasing age. Such deterioration affects the vital functions of the skin such as homeodynamic regulation of body temperature, fluid balance, loss of electrolytes and proteins, production of vitamin D, waste removal, immune surveillance, sensory perception, and protection of other organs against deleterious environmental factors. There are, however, harmful chemicals and toxins found in everyday cosmetics that consumers are now aware of. Thus, the natural beauty industry is on the rise with innovative technology and high-performance ingredients as more consumers demand healthier options. Therefore, the aims of this review are to give some critical insights to the effects of both intrinsic and extrinsic factors on excessive or premature skin aging and to elaborate on the relevance of natural beauty and natural anti-aging skincare approaches that will help consumers, scientists and entrepreneurs make the switch. Our recent investigations have shown the potential and relevance of identifying more resources from our rich natural heritage from various plant sources such as leaves, fruits, pomace, seeds, flowers, twigs and so on which can be explored for natural anti-aging skincare product formulations. These trending narratives have started to gain traction among researchers and consumers owing to the sustainability concern and impact of synthetic ingredients on human health and the environment. The natural anti-aging ingredients, which basically follow hormetic pathways, are potentially useful as moisturizing agents; barrier repair agents; antioxidants, vitamins, hydroxy acids, skin lightening agents, anti-inflammatory ingredients, and sunblock ingredients.
皮肤形态和生理学的恶化是衰老过程的第一个也是最早明显的先兆,随着年龄的增长,这种恶化会逐渐显现。这种恶化会影响皮肤的重要功能,如体温的体内动态调节、体液平衡、电解质和蛋白质的流失、维生素 D 的产生、废物清除、免疫监测、感觉感知以及保护其他器官免受有害环境因素的侵害。然而,日常化妆品中也存在消费者现在意识到的有害化学物质和毒素。因此,随着更多消费者对更健康选择的需求,天然美容行业正在兴起,具有创新技术和高性能成分。因此,本综述的目的是对内在和外在因素对皮肤过度或过早老化的影响提供一些批判性的见解,并详细阐述天然美容和天然抗衰老护肤方法的相关性,这将有助于消费者、科学家和企业家做出转变。我们最近的研究表明,从各种植物来源(如叶子、水果、果渣、种子、花朵、嫩枝等)中识别更多资源的潜力和相关性,这些资源可以用于天然抗衰老护肤品的配方。由于对合成成分对人类健康和环境的可持续性关注和影响,这些趋势性的叙述已经开始在研究人员和消费者中引起关注。基本遵循抗毒物作用途径的天然抗衰老成分,作为保湿剂、屏障修复剂、抗氧化剂、维生素、羟基酸、皮肤美白剂、抗炎成分和防晒霜成分具有潜在的用途。