Singh Arun Kumar, Malviya Rishabha, Prajapati Bhupendra, Singh Sudarshan, Yadav Deepika, Kumar Arvind
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India.
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva 384012, India.
Pharmaceuticals (Basel). 2023 Jun 19;16(6):899. doi: 10.3390/ph16060899.
Modern medicine has been working to find a cure for cancer for almost a century, but thus far, they have not been very successful. Although cancer treatment has come a long way, more work has to be carried out to boost specificity and reduce systemic toxicity. The diagnostic industry is on the cusp of a technological revolution, and early diagnosis is essential for improving prognostic outlook and patient quality of life. In recent years, nanotechnology's use has expanded, demonstrating its efficacy in enhancing fields such as cancer treatment, radiation therapy, diagnostics, and imaging. Applications for nanomaterials are diverse, ranging from enhanced radiation adjuvants to more sensitive early detection instruments. Cancer, particularly when it has spread beyond the original site of cancer, is notoriously tough to combat. Many people die from metastatic cancer, which is why it remains a huge issue. Cancer cells go through a sequence of events known as the "metastatic cascade" throughout metastasis, which may be used to build anti-metastatic therapeutic techniques. Conventional treatments and diagnostics for metastasis have their drawbacks and hurdles that must be overcome. In this contribution, we explore in-depth the potential benefits that nanotechnology-aided methods might offer to the detection and treatment of metastatic illness, either alone or in conjunction with currently available conventional procedures. Anti-metastatic drugs, which can prevent or slow the spread of cancer throughout the body, can be more precisely targeted and developed with the help of nanotechnology. Furthermore, we talk about how nanotechnology is being applied to the treatment of patients with cancer metastases.
近一个世纪以来,现代医学一直在努力寻找治疗癌症的方法,但迄今为止,成效并不显著。尽管癌症治疗已经取得了长足的进步,但仍需开展更多工作来提高特异性并降低全身毒性。诊断行业正处于技术革命的风口浪尖,早期诊断对于改善预后和提高患者生活质量至关重要。近年来,纳米技术的应用不断拓展,在癌症治疗、放射治疗、诊断和成像等领域展现出了成效。纳米材料的应用多种多样,从增强放射佐剂到更灵敏的早期检测仪器。癌症,尤其是癌细胞已经扩散到原发部位以外时, notoriously tough to combat(此句中notoriously tough to combat含义不明确,推测可能是“极难攻克”之类意思),许多人死于转移性癌症,这就是为什么它仍然是一个重大问题。在转移过程中,癌细胞会经历一系列被称为“转移级联”的事件,这可以用于构建抗转移治疗技术。传统的转移治疗和诊断方法存在必须克服的缺点和障碍。在本论文中,我们深入探讨了纳米技术辅助方法单独或与现有传统方法结合,在转移性疾病检测和治疗中可能带来的潜在益处。借助纳米技术,可以更精确地靶向和开发能够预防或减缓癌症在全身扩散的抗转移药物。此外,我们还讨论了纳米技术如何应用于癌症转移患者的治疗。