Dong X C, Li J M, Bai J Y, Liu Z Q, Zhou P H, Gao L, Li X Y, Zhang Y
Tianjin Centers for Diseases Control and Prevention, Tianjin 300011, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):638-641. doi: 10.3760/cma.j.cn112338-20200221-00146.
To investigate the clinical and epidemiological characteristics of 135 confirmed cases of COVID-19 in Tianjin. The clinical and epidemiological data of 135 cases of COVID-19 in Tianjin were collected, and the data were analyzed with descriptive method. The factors influencing the severity of the illness were analyzed. Among the 135 COVID-19 cases, 72 were males and 63 were females, the age of the cases was (48.62±16.83) years, and the case fatality rate was 2.22%. Local transmission caused 74.81% of the cases. A total of 33 clusters occurred, involving 85.92% of all COVID-19 cases. The median of the incubation period of COVID-19 was 6.50 days, the average generation interval was 5 days, and the household secondary transmission rate was 20.46%. Fever was the main symptom (78.63%), followed by cough (56.48%). Multivariate regression analysis indicated that age (=1.038, 95%: 1.010-1.167) and the number of chronic underlying diseases (=1.709, 95%: 1.052-2.777) were the risk factors of severe illness. Fever was the main symptom at the early phase of COVID-19 in Tianjin, and the local cluster cases accounted for high proportion in confirmed COVID-19 cases reported in Tianjin. Severe illness was prone to occur in people with old age and multi underlying diseases. Strict isolation of close contacts and intensive care of high-risk groups are the main measures to reduce the morbidity and case fatality of COVID-19.
为调查天津市135例新型冠状病毒肺炎确诊病例的临床和流行病学特征。收集天津市135例新型冠状病毒肺炎病例的临床和流行病学资料，采用描述性方法进行数据分析，并分析影响病情严重程度的因素。135例新型冠状病毒肺炎病例中，男性72例，女性63例，病例年龄为（48.62±16.83）岁，病死率为2.22%。本地传播导致74.81%的病例。共发生33起聚集性疫情，涉及所有新型冠状病毒肺炎病例的85.92%。新型冠状病毒肺炎潜伏期的中位数为6.50天，平均代间距为5天，家庭二代发病率为20.46%。发热是主要症状（78.63%），其次是咳嗽（56.48%）。多因素回归分析显示，年龄（=1.038，95%可信区间：1.010 - 1.167）和慢性基础疾病数量（=1.709，95%可信区间：1.052 - 2.777）是重症的危险因素。发热是天津市新型冠状病毒肺炎早期的主要症状，本地聚集性病例在天津市报告的新型冠状病毒肺炎确诊病例中占比高。老年人和有多种基础疾病的人易发生重症。严格隔离密切接触者和对高危人群进行重症监护是降低新型冠状病毒肺炎发病率和病死率的主要措施。
