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由于减肥手术导致伊曲康唑治疗孢子丝菌病失败。

Therapeutic failure with itraconazole in sporotrichosis due to bariatric surgery.

作者信息

Crestani Larissa, Souza Bruno de Castro E, Kakizaki Priscila, Valente Neusa Yuriko Sakai

机构信息

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2020 Mar-Apr;95(2):241-243. doi: 10.1016/j.abd.2019.04.015. Epub 2020 Feb 12.

DOI:10.1016/j.abd.2019.04.015
PMID:32165024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7175040/
Abstract

Sporotrichosis is a deep mycosis of subacute or chronic evolution, caused by the dimorphic fungus of the genus Sporothrix. The treatment is carried out with antifungal orally or intravenously. Therapeutic success can be affected by several factors, such as altered gastrointestinal physiology by surgery. More and more patients are submitted to bariatric surgeries and the literature for the alterations of the absorption of medications in this context is very scarce. We intend to contribute to a better understanding with this case report of cutaneous-lymphatic sporotrichosis in a patient after bariatric surgery without response to itraconazole treatment, even at high doses.

摘要

孢子丝菌病是一种亚急性或慢性进展的深部真菌病，由孢子丝菌属的双相真菌引起。治疗采用口服或静脉注射抗真菌药物。治疗成功可能受到多种因素影响，如手术导致的胃肠生理改变。越来越多的患者接受减肥手术，而关于这种情况下药物吸收改变的文献非常稀少。我们打算通过这份病例报告来促进对一名减肥手术后发生皮肤淋巴管型孢子丝菌病患者的更好理解，该患者即使使用高剂量伊曲康唑治疗也无反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/26cc99936531/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/a1de5a2fcd45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/17f6d43ca4df/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/26cc99936531/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/a1de5a2fcd45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/17f6d43ca4df/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c9/7175040/26cc99936531/gr3.jpg

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Epidemiology of Clinical Sporotrichosis in the Americas in the Last Ten Years.过去十年美洲临床孢子丝菌病的流行病学
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Susceptibility and resistance of Sporothrix brasiliensis to branded and compounded itraconazole formulations.

本文引用的文献

1
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics.孢子丝菌病：流行病学、病因发病机制、实验室检查及临床治疗的最新进展
An Bras Dermatol. 2017 Sep-Oct;92(5):606-620. doi: 10.1590/abd1806-4841.2017279.
2
Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission.孢子丝菌病的人畜共患病流行：从猫到人的传播
PLoS Pathog. 2017 Jan 19;13(1):e1006077. doi: 10.1371/journal.ppat.1006077. eCollection 2017 Jan.
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Successful treatment of terbinafine in a case of sporotrichosis.特比萘芬成功治疗一例孢子丝菌病。
巴西芽生菌对品牌和复方伊曲康唑制剂的敏感性和耐药性。
Braz J Microbiol. 2021 Mar;52(1):155-162. doi: 10.1007/s42770-020-00280-7. Epub 2020 Apr 24.
An Bras Dermatol. 2011 Jul-Aug;86(4 Suppl 1):S182-5. doi: 10.1590/s0365-05962011000700047.
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Mycoses in the elderly.老年人的真菌病。
Eur J Clin Microbiol Infect Dis. 2010 Jan;29(1):5-13. doi: 10.1007/s10096-009-0822-5. Epub 2009 Nov 13.
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A systematic review of drug absorption following bariatric surgery and its theoretical implications.减重手术后药物吸收的系统评价及其理论意义。
Obes Rev. 2010 Jan;11(1):41-50. doi: 10.1111/j.1467-789X.2009.00614.x. Epub 2009 Jun 2.