Labor Limbach, Heidelberg, Germany.
Eur J Clin Microbiol Infect Dis. 2010 Jan;29(1):5-13. doi: 10.1007/s10096-009-0822-5. Epub 2009 Nov 13.
Infections with dermatophytes are more prevalent in the elderly than in non-elderly adults; risk factors include local trophic disturbances, underlying diseases such as diabetes and a reduced oxygen supply due to diminished blood circulation. Vaginal mycoses are seldom found. In systemic yeast infections in patients of advanced age, Candida glabrata plays a relatively important role. The dimorphic fungus Coccidioides immitis is more prevalent in the elderly in endemic areas. Although there is no higher susceptibility to moulds in this age group, there are certain situations increasing the risk. The manifestations and symptoms of infection often differ from those of younger patients, which may hamper diagnosis. Deficits in organ function may influence the antifungal drug therapy. Preventive measures such as altering the social environment, avoiding malnutrition, as well as efforts to retard immunosenescence and to improve hygiene are important.
皮肤癣菌感染在老年人中比非老年人更为常见;危险因素包括局部营养障碍、糖尿病等基础疾病以及血液循环减少导致的供氧减少。阴道真菌感染很少见。在老年患者的系统性酵母感染中,光滑念珠菌相对较为重要。在地方性流行地区,双相真菌荚膜组织胞浆菌在老年人中更为常见。尽管该年龄组对霉菌的易感性没有增加,但存在某些增加风险的情况。感染的表现和症状往往与年轻患者不同,这可能会阻碍诊断。器官功能的缺陷可能会影响抗真菌药物治疗。改变社会环境、避免营养不良,以及努力延缓免疫衰老和改善卫生状况等预防措施很重要。