褪黑素治疗自闭症谱系障碍儿童失眠的疗效：一项荟萃分析。
Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis.
机构信息
Department of Nursing, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Pediatric Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
出版信息
Neuropediatrics. 2023 Jun;54(3):167-173. doi: 10.1055/s-0043-1761437. Epub 2023 Feb 24.
AIM
This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD).
METHODS
Comprehensive searches were conducted in the PubMed, EMBASE, and Web of Science databases from their inception to April 20, 2022. Data were extracted and assessed for quality by two researchers. Statistical analysis was performed using the Stata 15.0 software.
RESULTS
Four studies including 238 patients were included. The results showed that compared with the control group, melatonin could shorten the sleep-onset latency (standardized mean difference [SMD] = - 1.34, 95% CI: -2.19 to -0.48), reduce the number of awakenings (SMD = -2.35, 95% CI: -4.62 to -0.08), and prolong the total sleep time (SMD = 1.42, 95% CI: 0.5-2.33) in children with ASD.
CONCLUSION
Melatonin has a certain effect on relieving sleep disturbances in children with ASD, which can shorten sleep latency, reduce the number of awakenings, and prolong total sleep time. Larger studies are required to verify this hypothesis.
目的
本研究旨在评估褪黑素治疗自闭症谱系障碍（ASD）儿童失眠的疗效。
方法
从建库到 2022 年 4 月 20 日，全面检索 PubMed、EMBASE 和 Web of Science 数据库。由两名研究人员提取数据并评估质量。使用 Stata 15.0 软件进行统计分析。
结果
纳入 4 项研究共 238 例患者。结果显示，与对照组相比，褪黑素可缩短睡眠潜伏期[标准化均数差（SMD）=-1.34，95%CI：-2.19 至-0.48]，减少觉醒次数（SMD=-2.35，95%CI：-4.62 至-0.08），延长总睡眠时间（SMD=1.42，95%CI：0.5-2.33）。
结论
褪黑素对缓解 ASD 儿童睡眠障碍有一定作用，可缩短睡眠潜伏期，减少觉醒次数，延长总睡眠时间。需要更大的研究来验证这一假设。
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